Rheumatoid Arthritis Research and Therapies

This study identifies molecular subtypes and metabolic network changes in RA using multi-omics profiling, suggesting new therapeutic avenues.

This study uses spatial transcriptomics to identify distinct gene expression patterns in RA synovial fibroblasts and macrophages, revealing region- and cell-type-specific roles in inflammation and adaptive immunity.

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

This study shows that homocitrulline-specific immune responses induce RA-like pathology in HLA-DR4 transgenic mice, supporting the pathogenic role of anti-homocitrullinated protein autoantibodies in RA.

This study examines immunological and biochemical differences in rheumatoid arthritis patients compared to healthy controls, revealing sex-specific variations in inflammatory markers and organ function.

This study shows that inhibiting both glutaminolysis and autophagy reduces RA-FLS proliferation and arthritis in SKG mice.

The paper identifies three subpopulations of tissue-resident monocyte-lineage cells in inflammatory arthritis and examines their origins and responses to synovial disruption.

This study shows insulin influences epigenetic regulation of memory T cells in RA via H3K27ac-survivin mechanism, affecting metabolic activity and immune responses.

The paper identifies a novel memory B cell subset, COMB cells, enriched in autoimmune diseases and characterized by distinct transcriptional and epigenetic features.

This study shows that anti-citrullinated protein antibodies (ACPAs) in RA arise from germline antibodies targeting carbamylated proteins through affinity maturation and somatic hypermutations.

This study presents lineage tracing results from 18 myeloid-specific fate-mapping models in mouse peripheral blood and synovial tissue, validating synovial macrophage identification through flow cytometry and CITE-seq.

This study finds that housekeeping genes are significantly enriched in differentially expressed genes in rheumatoid arthritis, suggesting a potential role in RA pathogenesis.

This study identifies blood-based proteins associated with cardiovascular abnormalities in early rheumatoid arthritis using proteomic analysis and CMR imaging.

This study examines sex-specific differences in CD4 Th subsets and lifestyle factors in a RA cohort, finding sex-related variations in Th cell frequencies and dietary patterns.

The paper identifies RELM-positive perivascular macrophages that recruit monocytes to the synovium during arthritis onset, contributing to lining macrophage replenishment.

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

This study shows that activating FPR2 with a small molecule agonist reduces cardiac and lung damage in arthritic mice by decreasing inflammation and fibrosis.

The paper uses super-omics and PCAS to identify tumor-like molecular features in RA, including key proteins and oncogenic pathways.

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.

The paper creates a synovial fluid TCR, cytokine, and cell repertoire atlas to compare disease mechanisms across arthritic conditions using systems immunology approaches.

This study shows Wnt signaling drives inflammation in fibroblasts of inflammatory arthritis, suggesting it as a therapeutic target.

The paper shows that HOXD13 regulates gene expression in synovial fibroblasts, influencing primary cilia function and joint-specific RA pathology.

The paper uses an adapted ODE model to study synovial flares in palindromic rheumatism, showing how metastable locking can lead to progression to rheumatoid arthritis.

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

This study shows that low-intensity exercise reduces arthritis severity and inflammation in SKG mice with rheumatoid arthritis.

This study shows that PFS reduces bone destruction and shifts macrophage polarization from M1 to M2 in arthritis mice, suggesting its potential as an RA treatment.

This study uses Mendelian randomization to find a causal link between rheumatoid arthritis and increased atherosclerosis risk, with some specific arteries showing significant associations.