Rheumatoid Arthritis Research and Therapies

CAR-macrophage immunotherapy targeting fibroblast-like synoviocytes ameliorates inflammatory and degenerative arthritis

This study develops CAR-M2-FAP and CAR-M2-NCL therapies targeting FLS in RA and OA, showing reduced inflammation and joint damage in mouse models.

Indole-3-propionic acid nano-prodrugs sustain increased lymphoid exposure and alleviate experimental autoimmune arthritis

This study develops and tests nano-prodrugs of indole-3-propionic acid (IPA) to treat experimental autoimmune arthritis, showing improved lymphoid exposure and immunomodulatory effects.

The L-type voltage-gated Ca2+ channel CaV1.2 regulates fibroblast-like synoviocytes invasiveness during rheumatoid arthritis

This study identifies CaV1.2 as a Ca2+ influx channel that interacts with KCa1.1 to regulate invasiveness of RA-FLS through Ca2+ homeostasis.

Distinct synovial fluid B-cell differentiation and activation profiles in rheumatoid arthritis

The paper identifies distinct B-cell differentiation and activation profiles in RA synovial fluid, highlighting increased extrafollicular plasmablast differentiation in ACPA-positive RA.

Cathepsin K Mediates the Formation of Potential Rheumatoid Arthritis-Relevant Cis- and Trans-Spliced Peptides Compatible With HLA-DR4 Presentation

This study identifies cathepsin K-generated spliced peptides as potential autoantigens in RA, compatible with HLA-DR4 presentation.

ARID5B drives an inflammatory-to-destructive shift in pathologic fibroblast behavior

This study identifies ARID5B as a transcription factor that shifts inflammatory fibroblasts from an inflammatory to a destructive phenotype in arthritis.

CX3CR1 And MHCII Define Distinct Synovial Macrophage Populations With Conserved Inflammatory Response Across Mouse Models Of Rheumatoid Arthritis.

The paper identifies four distinct synovial macrophage populations in RA models and shows conserved inflammatory responses across conditions.

Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis

Peptide allosteric inhibitor of TNFR1 signaling attenuates inflammation and rheumatoid arthritis pathology in human TNF transgenic mice

This study evaluates a peptide-based inhibitor of TNFR1 signaling in a human TNF transgenic mouse model of RA, showing reduced inflammation and improved disease outcomes.

ARL15 promotes inflammatory fibroblast activation and disease severity in rheumatoid arthritis: integrated transcriptomic and collagen-induced arthritis model analyses

This study identifies ARL15 as a pro-inflammatory driver of rheumatoid arthritis by integrating transcriptomic, single-cell, and in vivo analyses, showing its therapeutic potential through inhibition in a mouse model.

A new humanized TCR transgenic mouse model to study citrullinated tenascin C reactive T cells relevant to rheumatoid arthritis

An APOC1+ inflammatory CAF-like state drives a senescent, treatment-resistant niche in rheumatoid arthritis

The paper identifies a treatment-resistant fibroblast state in RA synovitis that drives chronic inflammation through senescence-associated mechanisms and highlights therapeutic targets beyond cytokine inhibition.

Developing High Content Imaging Functional Panels to Characterize Synovial Fibroblasts in Rheumatoid Arthritis

This paper develops a high-content imaging assay to analyze synovial fibroblasts in arthritis, revealing disease-specific functional heterogeneity and identifying IL-1β as a key driver of autophagy.

Novel loci and multi-omics risk models for rheumatoid arthritis through a million-participant genome-wide association meta-analysis

This paper identifies novel genetic loci and polygenic risk scores for rheumatoid arthritis using a million-participant meta-analysis and shows improved risk prediction with metabolomic integration.

Neurostructural and molecular evidence of advanced brain aging in rheumatoid arthritis

This study shows rheumatoid arthritis is linked to accelerated brain aging, evidenced by increased brain-age gap and neurostructural changes.

Cross-presentation of citrullinated antigens drives cytotoxic CD8+ T cell responses in rheumatoid arthritis

The paper identifies a mechanism where TLR4-driven cross-presentation of citrullinated antigens by dendritic cells and autoreactive B cells activates CD8+ T cells in rheumatoid arthritis.

Metabolic-secretory decoupling defines a disease-intrinsic state in rheumatoid arthritis monocytes

The paper identifies a stable metabolic-secretory defect in RA monocytes across activation states using multi-omics analysis, linking reduced glycosylation to disease mechanisms.

Integrating virtual cell modeling with patient-derived transcriptomics to uncover target signals in rheumatoid arthritis

The paper evaluates virtual cell models in rheumatoid arthritis by comparing empirical and virtual perturbations in patient-derived T cells, finding preserved target priorities with disease-specific shifts.

Bistable attractor dynamics in difficult-to-treat rheumatic disease: a multi-axis ODE framework with cross-disease transcriptomic evidence

The paper develops a multi-axis ODE framework to model bistable dynamics in difficult-to-treat rheumatic diseases, supported by cross-disease transcriptomic analysis.

Circulating Immune Cells are Associated with Non-Inflammatory Pain in Rheumatoid Arthritis

The paper identifies immune cell populations and gene expression differences associated with non-inflammatory pain in RA patients using flow cytometry and single-cell RNA-seq.

Autophagy shapes the peptide repertoire of rheumatoid arthritis-associated HLA class II alleles

This study shows autophagy contributes to MHC class II presentation of RA-related peptides in HLA-DRB1*04:01 alleles, with 30% of peptides differing between autophagy sufficient and deficient cells.

Synovial fibroblast niche shapes the efficacy - safety dynamics of JAK inhibition in rheumatoid arthritis

This study identifies synovial fibroblasts as key targets of JAK inhibition in RA and reveals cytokine- and drug-driven mechanisms affecting JAKi efficacy and safety.

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis.

The paper identifies fibroblast-derived neurotrophin signaling as a driver of abnormal vascular maturation in RA synovia and shows that neurotrophin inhibitors can reverse this process.

Autoantigen-specific CD8+ T-cell signature in Rheumatoid Arthritis

This study identifies HLA class I-restricted CD8+ T-cell epitopes in RA and shows how citrullination affects antigen recognition and T-cell clonotype stability.

TREM2 agonist antibody rebuilds the resident synovial macrophage lining barrier in rheumatoid arthritis

This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.

Investigating the impact of obesity as an immunological instigator on young-onset arthritis using perturbation-based simulation

This paper uses perturbation-based simulation to estimate the impact of childhood obesity on young-onset arthritis prevalence, finding that reducing BMI could prevent 3-5% of cases.

Synovial lining expressed mechanosensor PIEZO1 drives inflammation-permissive macrophage phenotypes and joint inflammation

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

Fibroblasts sense spatial proximity via an EGFR CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis

The paper identifies a spatial proximity-sensing mechanism in fibroblasts that restores quiescent synovial lining during RA remission through the EGFR-CREB5 axis.

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.