Suicide and Self-Harm Studies

Offset analgesia and onset hyperalgesia: A comparison between women with non-suicidal self-injury and healthy women

The paper compares offset analgesia and onset hyperalgesia responses between women with non-suicidal self-injury and healthy controls, finding weaker onset hyperalgesia in the NSSI group.

Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression

This study examines how non-suicidal self-injury (NSSI) interacts with depression severity in decision-making, finding that NSSI individuals are more risk-averse but show increased risk-taking as depression worsens.

Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population

This study identifies genetic loci and variants associated with suicidal behaviors and alcohol use disorders in an American Indian population using whole-genome sequencing.

Polygenic contributions to suicidal thoughts and behaviors in a sample ascertained for alcohol use disorders

The paper uses polygenic risk scores from GWAS to assess their association with suicidal thoughts and behaviors in a sample with alcohol use disorders, finding significant contributions from multiple PRS.

Examining Blunted Initial Response to Reward and Recent Suicidal Ideation in Children and Adolescents Using Event-Related Potentials: Failure to Conceptually Replicate Across Two Independent Samples

Transcriptome profiling of the dorsomedial prefrontal cortex in suicide victims

This study identifies gene expression changes in the dorsomedial prefrontal cortex of suicide victims compared to controls, highlighting pathways related to cytokine and glutamatergic signaling.

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

The paper examines genetic overlaps between suicide-related behaviors and substance use disorders using GWAS summary statistics and finds significant genetic correlations but little evidence of causation.

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Suicidal thoughts, behaviors, and event-related potentials: A systematic review and meta-analysis

This meta-analysis evaluates the effectiveness of event-related potentials in differentiating groups with and without suicidal thoughts and behaviors, finding no significant relationships and highlighting severe underpowering in the literature.

Rare protein coding variants implicate genes involved in risk of suicide death

The paper identifies five rare SNPs associated with suicide death using genetic data from the USGRS and controls, highlighting their potential role in suicide risk and related biological processes.

Default Mode and Salience Network Alterations in Suicidal and Non-Suicidal Self-Injurious Thoughts and Behaviors in Adolescents with Depression

The paper examines brain network coherence differences between adolescents with depression and suicidal or non-suicidal self-injurious thoughts, identifying specific neural patterns associated with these behaviors.

Complex multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidal behaviors

The paper investigates gene-environment interactions between polysubstance dependence and suicidal behaviors using two cohorts, finding significant associations and gene clusters linked to these interactions.

Brain Abnormalities Associated with Self-Injurious Thoughts and Behaviors: A Meta-Analysis of Neuroimaging Studies

This meta-analysis evaluates brain abnormalities associated with self-injurious thoughts and behaviors, finding no robust evidence for structural abnormalities and mixed results for functional ones.

Analysis of Suicidal Patients Admitted to The Emergency Rooms and Their Intensive Care Requirements, A Double-Center Study in Turkey

This study analyzes suicide attempt patients in emergency departments and ICU requirements, finding high rates of domestic violence as a cause and ICU admission in 30.5% of cases.

Novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide.

This paper identifies three novel genome-wide significant loci for suicidality using UK Biobank data and finds strong genetic correlations with depression and increased polygenic risk for completed suicide.

Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide

This paper identifies significant heritability of suicide attempt using two independent datasets and shows genetic overlap with insomnia and psychiatric disorders.

Association of a lincRNA postmortem with suicide by violent means and in vivo with aggressive phenotypes

The paper replicates a postmortem association of LINC01268 with violent suicide and links it to in vivo aggression and prefrontal cortex function in living individuals.

Genomewide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide

The paper identifies 207 genes associated with completed suicide using genomic data from 43 high-risk Utah families, finding four significant variants linked to suicide risk.