Cellular Mechanics and Interactions

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

The paper examines how tissue stiffness scales with collagen levels across different tissues and finds sub-linear scaling that aligns with cellularized gels, suggesting contractility-driven strain inhibition of collagen degradation.

This study identifies a mechanical imbalance between normal and transformed cells in epithelial tissue, showing that transformed cells are more compressible due to weakened adhesions, driving cell competition and homeostasis.

This paper introduces a hydrogel soft lithography technique that reduces microfeature dimensions by 2-fold and enables molding of super-soft materials, revealing curvature-dependent cell alignment patterns.

This study shows that septins regulate T cell migration modes by switching between amoeboid and mesenchymal movement, with mesenchymal migration relying on microtubules and dynein motors.

This study shows that PDZ domains from afadin and ZO-1 act as mechanosensors, forming catch bonds or weakening under mechanical force, affecting cell-cell adhesion stability.

The paper identifies synergistic regulation of actin networks by supervillin and myosin II, leading to stress fiber disassembly and cell rounding.

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.

This study develops a microfluidic device to generate controlled disturbed flows and shows how bidirectional oscillatory shear stress alters endothelial cell morphology and nuclear organization.

This paper develops an in vitro platform to study how mechanical forces affect actin-binding protein interactions in multi-filament networks, revealing that force enhances -catenin binding to small filament bundles.

The paper defines a mechanical fingerprint to characterize intracellular mechanical states and reveals cell type-specific differences related to biological function.

This study identifies how alternating cell polarity in Scaptodrosophila follicle cells integrates chemical and mechanical cues to drive tissue morphogenesis.

This study presents a label-free method to analyze mechanical properties of bladder cancer spheroids at different stages of progression, revealing viscoelastic behavior and heterogeneity.

The paper shows that nanoroughness induces a glioblastoma-like phenotype in astrocytes through spheroid formation, MMP2 activation, and gene expression changes.

The paper shows that actin bundle lengths in cells follow a non-Gaussian distribution with variance proportional to the square of the steady-state length, challenging balance point models.

The paper investigates TIAM-1's role in regulating protrusions during dorsal intercalation in C. elegans embryos, showing its GEF domain promotes protrusions while its N-terminal domains suppress ectopic ones.

This study shows that axon morphology and function are influenced by membrane mechanics, with activity modulating cholesterol levels and affecting conduction velocity.

The paper identifies DLC1's role in regulating RhoA activity through the talin interactome, linking mechanical memory to cardiac phenotype changes.

The paper investigates how mesoderm invagination affects ectoderm extension during Drosophila gastrulation and finds that cellular mechanisms of axis extension are robust to this mechanical pull.

This study identifies signatures of jamming in the Cellular Potts Model by analyzing mobility, diffusion, and cell shape changes under varying adhesion and confinement conditions.

The paper uses human mammary organoids to show that configurational entropy drives tissue structural heterogeneity by linking structural parameters to molecular and microenvironmental factors.

The paper investigates how distinct cellular dynamics regulate simultaneous morphogenetic processes in Drosophila hindgut development.

The paper shows how mechanical coupling between Myosin-II activation and adhesion/de-adhesion drives a cell contractile wave during Drosophila tissue morphogenesis.

The paper identifies new proteins involved in apical ECM biology in C. elegans and shows SYM-3/FAM102A and SYM-4/WDR44 function in trafficking but not ECM protein deposition.

This study identifies actin polymerization as the mechanism driving lumen formation in human epiblast models, showing it initiates lumen opening and transitions to pressure-driven growth as the lumen expands.

The paper uses single-cell phenomics to study DVE cell migration in mouse embryos, revealing mechanical heterogeneities and how surrounding cells facilitate collective migration.

The paper identifies a Rho1-dependent medioapical actomyosin network that coordinates cell behavior during Drosophila eye development.

The paper shows pulsatile myosin dynamics stabilize tissue folding during embryonic development by counteracting cell-to-cell myosin fluctuations.