Reproductive tract infections research

Characterisation of vaginal Lactobacillus isolates from South African women towards the development of a biotherapeutic to optimise the vaginal microbiome

The paper characterizes vaginal Lactobacillus isolates from South African women to identify biotherapeutic candidates that can optimize the vaginal microbiome and reduce HIV risk.

Chemotaxis and selective interactions of Trichomonas vaginalis with the vaginal bacteria

This study shows Trichomonas vaginalis exhibits chemotaxis toward Lactobacillus gasseri and avoids Gardnerella vaginalis, revealing pH taxis and selective interactions with vaginal bacteria.

Cervicovaginal Dysbiosis in HPV-Negative Women: Metagenomic Evidence Implicates Achromobacter in Female Infertility

This study identifies Achromobacter as a microbial biomarker associated with infertility in HPV-negative women through metagenomic analysis of cervicovaginal microbiota.

Genomic epidemiology of Neisseria gonorrhoeae isolates from the G-ToG clinical trial, 2014-2016

The paper analyzes whole genome sequences of Neisseria gonorrhoeae isolates from the G-ToG trial to characterize gonococcal diversity and AMR patterns in England, showing sexual network-driven phylogenetic structure and AMR differences between transmission groups.

Exopolysaccharides of Lactobacillus crispatus mediate key balancing interactions with the vaginal mucosa

This study identifies exopolysaccharides (EPS) from Lactobacillus crispatus as critical for modulating immune responses in the vaginal mucosa, with EPS disruption leading to pro-inflammatory effects.

Identification of collaborative cross mouse strains susceptible to chlamydial induction of hydrosalpinx

This study identifies Collaborative Cross mouse strains susceptible to chlamydial induction of hydrosalpinx, revealing strain-specific differences in infection and pathology outcomes.

Resource landscape shapes the composition and stability of the human vaginal microbiota

This study introduces a mathematical model to explore how nutritional resources shape the composition and stability of the human vaginal microbiota, showing that exclusive access to certain nutrients correlates with bacterial vaginosis dominance.

Putative azithromycin-resistance mutations in Chlamydia trachomatis are globally distributed but arose before azithromycin was discovered

The paper analyzes azithromycin resistance mutations in Chlamydia trachomatis genomes, finding common mutations in rplV that predate azithromycin's clinical use.

Sialidase variability in Gardnerella: genetics, taxonomy, function, and clinical presentation

This study examines sialidase variability in Gardnerella isolates from BV-positive and negative samples, finding no clear link between taxonomy, sialidase genes, and BV status.

Comprehensive 16S rRNA gene sequencing and meta-transcriptomic analyses in female reproductive tract microbiota: Two molecular profiles with different messages

This study compares 16S rRNA gene sequencing and meta-transcriptomic analyses of endometrial microbiota, finding weak correlation in low-biomass environments and highlighting the value of RNA-based functional insights.

Divergent myelopoiesis and macrophage polarization underlie host susceptibility to chronic Chlamydia trachomatis infection

This study shows that genetic differences in mice lead to distinct myelopoiesis and macrophage polarization outcomes during Chlamydia trachomatis infection, affecting whether the infection becomes chronic.

Effect of Azithromycin treatment on the microbial composition, functional dynamics and resistomes of endocervical, vaginal and rectal microbiomes of women in Fiji with Chlamydia trachomatis infection

This study examines how azithromycin affects microbial composition, function, and resistance genes in endocervical, vaginal, and rectal microbiomes of women with Chlamydia trachomatis infection.

The Neovaginal Microbiota, Symptoms, and Local Immune Correlates in Transfeminine Individuals with Penile Inversion Vaginoplasty

The paper characterizes the neovaginal microbiota and cytokine profiles in transfeminine individuals post-vaginoplasty, identifying bacterial clusters linked to immune responses and symptoms.

The vaginal microbiota, symptoms, and local immune correlates in transmasculine individuals using sustained testosterone therapy

The paper examines vaginal microbiota, symptoms, and immune markers in transmasculine individuals on testosterone therapy, finding Lactobacillus dominance linked to adverse symptoms and inflammation.

The Vaginal Microbiome in Women Recently Experiencing BV and UTI

The paper analyzes vaginal microbiome data from 10,003 women to compare microbial signatures associated with bacterial vaginosis and urinary tract infections.

Lactobacillus iners dominates the vaginal microbiota of healthy Italian women of reproductive age.

This study tracks vaginal microbiota changes in Italian women across menstrual phases, finding Lactobacillus iners as dominant and highlighting population-specific patterns and hormonal associations.

Circulating Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women

This study examines circulating T cell immunity to Chlamydia trachomatis in South African adolescents and young women, finding that immune response magnitude and quality correlate with infection clearance and mucosal inflammation.

Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction

The paper shows polyamines alter G. vaginalis-induced epithelial dysfunction by changing transcriptomic profiles and inflammatory responses.

Tetramer formation of CpoS facilitates Inc-Inc interactions during Chlamydia trachomatis infection

This study shows CpoS forms tetramers that mediate Inc-Inc interactions and Rab GTPase engagement, facilitating vesicle trafficking during Chlamydia trachomatis infection.

Synergistic therapeutic effects of endolysin BNT331 and a Lactobacillus crispatus consortium in a human vagina chip model of bacterial vaginosis

Endolysin BNT331 combined with Lactobacillus crispatus reduces bacterial load and suppresses inflammation in a human vagina chip model of bacterial vaginosis.

Vaginal epithelial estrogen receptor α regulates vaginal pH without detectable changes in glycogen content or microbial diversity in mice

Vitamin B2 Production by Vaginal Lactobacilli Promotes Symbiosis

This study identifies riboflavin production by vaginal lactobacilli and shows its role in modulating host immune responses and redox balance.

The female intimate microbiome space

The paper examines microbial dispersal across female intimate body sites and finds lactobacilli are unexpectedly abundant on breast skin.

Clinical Candida Lactobacillus Isolate Pairs Reveal Distinct Host-Pathogen Interactions in a Vaginal Epithelial Model

The paper examines host-pathogen interactions between Candida albicans and Lactobacillus isolates in a vaginal epithelial model, showing divergent effects on cytotoxicity and pH.

Strain-level differences in Gardnerella urinary tract persistence and pathogenesis are consistent with comparative phylogenomic analyses.

This study compares Gardnerella strains in vivo to identify genomic factors associated with urinary tract persistence and pathogenesis, finding clade-specific differences in virulence and persistence.

Association Between Vaginal Community States and Preeclampsia Status in Pregnant Individuals

The paper reanalyzes 16S rRNA sequencing data to assess associations between vaginal community states and preeclampsia status, finding subtype differences in Lactobacillus spp. and reduced prevalence of D-lactic acid-producing types in preeclampsia.

Computational Microbiome Pharmacology Analysis Elucidates the Anti-Cancer Potential of Vaginal Microbes and Metabolites

The paper develops a systems biology framework called the Pharmacobiome to analyze the anti-cancer potential of vaginal microbes and metabolites by comparing their effects on host gene expression to known drugs.

Identifying a Vaginal Microbiome-Derived Selective Antibiotic Metabolite via Microbiome Pharmacology Analysis

This study identifies a vaginal microbiome-derived antibiotic metabolite, Hydroxyisocaproate, using a systems biology approach to improve BV treatment.

Metabolism of Lactobacillus and Gardnerella vaginalis in vaginal defined media

This study characterizes the metabolism of Lactobacillus and Gardnerella vaginalis in vaginal defined media, showing differences in lactate production and fermentation strategies compared to complex media.

Genetic transformation of Gardnerella species and characterization of vaginolysin and sialidase mutants

This study develops genetic tools for Gardnerella species, creating mutants of vaginolysin and sialidase to investigate their roles in bacterial vaginosis.