Memory and Neural Mechanisms

Neural Dissociation of Cognitive Maps and Graphs in the Human Brain

The paper dissociates neural representations of cognitive maps and graphs in the human brain using fMRI and representational similarity analysis.

Evidence-Gated Plasticity and Context-Dependent Consolidation for Multi-Goal Learning in Spiking Neural Networks

This paper introduces evidence-gated plasticity (EGP) for multi-goal learning in spiking neural networks, showing improved reward and target selectivity with target-context EGP.

A Computational Model Captures Orexin-Dependent Modulation of Memory Consolidation.

The paper develops a computational model linking orexinergic tone to memory consolidation through SWR statistics, showing task-dependent effects on memory performance.

Moving object generates topographic responses in the majority of entorhinal neurons

The paper shows that moving visual stimuli elicit topographic and directional responses in most entorhinal neurons, revealing visual input's role in shaping their activity.

Path Integration Promotes Flexible Navigational Decision Making

This study shows that rats using path integration for navigation show better generalization to novel situations compared to those using visual landmarks.

Rewiring the Human Brain: On the Fabric of Associative Thinking

This paper proposes a model for how structural plasticity enables the formation of concept engrams in the human brain through synaptic creation, and demonstrates how activating a concept can trigger related concepts via percept-concept loops.

Latent dentate gyrus engrams formed in infancy scaffold adult learning

The paper shows that infant-formed engrams persist as latent memories in mice and support adult learning through reactivation of dentate gyrus ensembles.

Directionally tuned signals in mouse visual and subicular cortex during passive rotation

This study compares directional activity in mouse visual and subicular cortex during passive rotation, finding differences in how visual cues influence their directional tuning.

Human claustrum neurons encode uncertainty and prediction errors during aversive learning

This study shows human claustrum neurons encode uncertainty and prediction errors during aversive learning, with distinct temporal profiles compared to anterior cingulate cortex.

Reduced dorsal CA1 Activity Limits Retention of the Temporal Component of Declarative Memory in the Cntnap2 Knockout Mouse Model of Autism

This study shows that reduced dorsal CA1 activity in Cntnap2 knockout mice impairs temporal memory retention and flexible spatial memory, linking hippocampal dysfunction to cognitive inflexibility in autism.

Fear Learning Induced Brain Dynamics Predict Individual Extinction Memory Expression following Transcranial Magnetic Stimulation

The paper shows that fear learning reorganizes brain activity, and this reorganization predicts extinction memory expression when modulated by TMS during extinction learning.

Extended amygdala function is governed by threat probability, not uncertainty

The paper challenges the canonical model of anxiety by showing that threat probability, not uncertainty, is more strongly associated with threat anticipation and EA regions.

Sparse coding at the input stage of the hippocampus enables fast learning

This study shows that sparse coding at the input stage of a neural network enhances learning speed but reduces generalization, mirroring the hippocampus's dentate gyrus.

Reversible inhibition of medial septum interneurons abolishes initial acquisition of new place-reward associations and reveals a progressive reduction in dependence on medial septal function

This study shows that reversible inhibition of medial septum interneurons impairs initial learning of new place-reward associations but not long-term retention, suggesting a shift from hippocampus-dependent to non-hippocampus-dependent spatial strategies.

Subcortical-hippocampal circuits for mediating impaired contextual fear memory after an acute shift of the light/dark phase

This study investigates how an acute light-dark phase shift affects fear memory in mice, identifying overactivation of the SuM-DG pathway and orexinergic system as key factors.

A cortical-hippocampal communication undergoes rebalancing after new learning

This study investigates how cortical-hippocampal communication changes after learning, finding that specific CA1 sublayers undergo reorganization during post-training sleep.

Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A high-resolution whole-brain fMRI investigation

This study investigates how temporal interference affects mnemonic discrimination using fMRI, finding that it modulates activity in extrahippocampal MTL and cortical regions.

Brain Regions Involved in Object-Location Memory Across the Human Lifespan: A Systematic Review and Activation Likelihood Estimation Meta-Analysis of Task-Based fMRI

This paper conducts a systematic review and meta-analysis of fMRI studies on object-location memory, identifying key brain regions involved in encoding and retrieval and age-related differences in neural activity.

Stressor Identity Shapes Reactivity To Subsequent Stress

This study shows that different types of acute stressors affect future fear learning differently in mice, with shock and social defeat enhancing fear memory recall, while restraint stress does not.

A population code for semantics in human hippocampus

The paper investigates how semantic information is encoded in human hippocampal activity during speech processing, finding that distributed neural patterns capture semantic relationships similar to language models.

Cellular Determinants of CA1 Pyramidal Cell Recruitment during Sharp-Wave Ripples

The paper identifies cellular mechanisms determining CA1 pyramidal cell recruitment during hippocampal ripples, showing depolarization and excitability drive participation differences.

Medial septum glutamatergic neurons support speed coding and grid cell spatial stability in the medial entorhinal cortex

This study identifies medial septal glutamatergic neurons as essential for maintaining grid cell spatial stability and speed coding in the medial entorhinal cortex through optogenetic silencing and network modeling.

Ongoing brain state dynamics shape spontaneous awake reactivation and its relationship with memory

This study shows that awake memory reactivation is embedded in dynamic whole-brain states that influence memory retention outcomes.

Network Adaptability Governs Resilience and Susceptibility to Social Defeat

The paper investigates resilience and susceptibility to social defeat stress in mice using brain imaging, identifying structural and network-level differences associated with coping mechanisms.

Rapid spatial cognition in mice, with and without neocortex and hippocampus

Naive mice learn a 9-turn route in a reconfigurable 3D maze within about 20 rewards; mutants lacking neocortex and hippocampus also learn, remember and generalize, though early exploration is inefficient.

Theta sweeps accelerate cognitive map learning by broadcasting information to unvisited regions

This paper proposes that theta sweeps in grid and place cells accelerate cognitive map learning by broadcasting sensory information to unvisited regions, and presents a computational model to test this hypothesis.

Different hippocampal subfield volumes predict source memory performance and general cognitive ability in an adult lifespan sample

The paper examines associations between hippocampal subfield volumes and cognitive performance in adults across the lifespan, finding subfield-specific links to memory and non-mnemonic cognition that are age-invariant.

Resolving temporal threat uncertainty by observational learning involves the amygdala, hippocampus and anterior insula

This study investigates how humans learn to resolve temporal threat uncertainty through observational learning, identifying neural correlates in the amygdala, hippocampus, and anterior insula.

Hippocampal Ring Finger Protein 10-dependent signaling supports cognitive flexibility

This study identifies RNF10-mediated signaling in the dorsal hippocampus as essential for cognitive flexibility by linking NMDAR activation to transcriptional programs that support adaptive behavior.

Abstract representation in the hippocampus predicts spontaneously adopted structure-based behavioral strategy

The paper shows that abstract hippocampal representations predict the use of structure-based behavioral strategies in mice during learning.