Fungal and yeast genetics research

The paper identifies how methionine reprograms yeast metabolism to support proliferation by rewiring key metabolic pathways and co-opting a stress response regulator.

The paper measures meiotic recombination rates in yeast strains and finds recombination correlates with sequence similarity and is reduced in homozygous genotypes.

This study identifies Sfp1 as a master regulator of cell growth and division in yeast by coordinating gene expression through two distinct promoter binding modes.

The paper identifies two yeast genes, ITT1 and RPS1A, whose deletion increases heavy metal sensitivity by affecting URE2 mRNA translation.

This study analyzes the genome of Candida albicans to show that mutation and cryptic sexual recombination drive its evolution, with non-random distribution of SNPs and LOH events.

The paper identifies DNA-binding preferences of Ste12 in yeast and shows how mutations shift its preference toward mating or invasion.

The paper identifies transposable element insertions as a mechanism regulating Zmr1 expression and melanin accumulation in the fungal pathogen Zymoseptoria tritici.

The paper describes a C-SWAT library for high-throughput tagging of yeast ORFs and validates it by tagging the yeast proteome with fluorescent proteins.

The paper investigates the long-term stability of heterologous protein antigens in yeast cells and proposes a strategy to assess their integrity.

This study compares kinomes of 12 Fusarium oxysporum isolates and seven ascomycete genomes, identifying kinase expansions linked to environmental sensing and host specificity.

The paper generates an ORFeome collection and associated tools for studying Candida albicans pathogenesis.

This study shows that Candida albicans rapidly generates genotypic and phenotypic diversity in the mouse oral cavity, with higher mutation rates compared to in vitro conditions.

The paper identifies a regulatory network involving MAP-Kinase pathways and transcription factors that maintain cell integrity and mediate communication and cell fusion in Neurospora crassa.

The paper identifies secreted and cell membrane proteins in ten Aspergillus species and finds their secretomes are more antigenic and structurally similar to known drug targets.

This study reports the whole genome sequence of Cordyceps guangdongensis, providing genomic resources for further genetic and biological research.

The paper links gene expression variation to a stress defense trait in yeast by identifying a QTL hotspot locus affecting ethanol-induced cross protection.

The paper maps meiotic recombination in Cryptococcus deneoformans, finding lower recombination rates in unisexual reproduction compared to bisexual crosses.

The paper shows that fructophilic yeasts in the W/S clade lost and reacquired alcoholic fermentation genes via horizontal gene transfer, adapting to high sugar environments.

The paper develops a high-throughput genetics method for Rhodosporidium toruloides, identifies essential genes, and reveals key processes in lipid metabolism.

The paper analyzes genome data from dimorphic fungi to identify evolutionary mechanisms underlying their adaptation to human hosts.

The paper identifies gene clusters in fungal genomes associated with phenylpropanoid degradation and links their organization to ecological lifestyles.

The paper investigates how gene expression changes during heat shock adaptation in yeast are constrained by metabolic requirements and shows these changes are specific to heat shock.

This study shows that the INO80 chromatin-remodelling complex coordinates metabolic homeostasis with cell division in S. cerevisiae by regulating periodic gene expression.

The paper quantifies mutation effects on TDH3 promoter activity in yeast across environments and finds natural selection limits plasticity between glucose and galactose.

The paper uses single-cell RNA-seq to study stress response heterogeneity in yeast, finding regulatory variation and decoupled transcription-factor activation.

This study maps cis-regulatory variation in budding yeast with high-resolution eQTLs, revealing roles of non-promoter variants and selection pressures on gene expression.

The paper identifies non-catalytic phenotypes in yeast enzymes, suggesting moonlighting activities beyond their annotated functions.

The paper constructs a network of reactions for plant cell wall polysaccharide degradation in Neurospora crassa by integrating multiple data types and identifies a key transcription factor in mannan degradation.

The paper uncouples glucose sensing from metabolism in yeast by using a cellobiose pathway, revealing new regulatory mechanisms for ATP management and energy homeostasis.

The paper examines meiotic recombination differences between Saccharomyces cerevisiae and Lachancea kluyveri, finding significant variations in recombination rates, crossover patterns, and hotspot conservation across evolutionary distances.