Fungal and yeast genetics research

The paper shows that genetic suppression interactions are largely conserved across different yeast genetic backgrounds, suggesting potential for therapeutic applications.

The paper identifies a universal mechanism by which cells adapt gene expression to different carbon sources through calcium signaling regulated by glycolytic metabolites and ionic memory of past carbon sources.

This study identifies essential genes in the mating-type locus of Cryptococcus neoformans, showing that four genes are essential for viability while MYO2 is critical for pathogenicity despite not being essential.

The paper identifies an inverted architecture of PIR proteins in Neurospora crassa and shows they function as cell wall stabilizers similar to yeast PIRs.

This study shows that Swi4-dependent transcription couples cell size to cell cycle commitment in budding yeast by regulating Swi4 accumulation and Start timing.

This study examines how introgression affects recombination patterns in yeast by analyzing crossover and non-crossover rates in crosses with and without introgression.

This paper examines horizontal chromosome transfer in fungi, highlighting a preference for accessory chromosomes and proposing mechanisms for their regulated transfer.

The paper introduces a method to quantify gene disruption fitness effects using TIS data in yeast, showing that average read counts per insertion site provide a robust fitness metric.

The paper tests if genetic divergence in the MAT-proximal region of Podospora anserina suppresses recombination, finding that sequence divergence alone is insufficient.

This study identifies trehalose as a mediator of fluconazole tolerance in C. glabrata by altering sterol composition, showing that trehalose deficiency reduces drug tolerance.

The paper identifies Bud8 and Bud5 as key components of the spore polarity site in budding yeast, showing their role in de novo polarity establishment independent of mating cues.

This study identifies FgKnr4 as a conserved fungal protein critical for cell wall integrity and pathogenicity, validated through network analysis and functional studies in Fusarium graminearum and Zymoseptoria tritici.

The paper describes updates to the Candida Genome Database, focusing on annotation, visualization, and integration of clinical data for research on Candida species.

The paper investigates transcriptional and morphological changes in three strains of Maudiozyma bulderi at low pH, identifying genes involved in acidophilic adaptation.

This study investigates how suppression of glycolysis affects sugar-induced cell death in yeast, finding that reducing glycolytic activity decreases cell death and ROS levels.

The paper compares transcriptomics and proteomics data from wild-type and peroxisome-deficient yeast to identify changes in cellular processes due to peroxisome loss.

The paper identifies Pak1 as a key protein mediating negative feedback in yeast to enable multiple polarity sites and budding.

This study identifies stress-dependent changes in Hog1 pathway regulation in C. albicans, revealing Ssk1's role as a scaffold and its impact on Hog1 phosphorylation under different stress conditions.

The paper uses phosphoproteomics to show that TORC1 is reactivated by pheromone signaling in fission yeast during sexual reproduction, supporting spore viability.

The paper introduces a method to reduce plasmid transformation multiplicity in yeast during electroporation, improving mono-transformation rates without reducing efficiency.

This study shows that deleting the MpkA kinase in Aspergillus nidulans alters mycelial material mechanical properties, including increased tensile strength and resistance to fragmentation.

The paper investigates how dynamic stress gradients affect cell growth and signaling in yeast, finding that gradual stress enhances growth with minimal volume reduction through a logarithmic MAPK signaling mechanism.

This study identifies crosstalk between the CWI and SIN pathways in fungi, showing that it enables hyperseptation under echinocandin stress, which contributes to resistance.

This study shows that Gcn2 compensates for Hog1/p38 loss in C. neoformans during thermal stress, rescuing adaptation and virulence through crosstalk between these pathways.

This paper develops ectopic DNA integration and marker-free CRISPR/Cas9 methods for the halotolerant yeast Hortaea werneckii to enable genetic studies of its unique physiology and cell biology.

This study shows that cytosolic acidification regulates Sch9 localization, affecting TORC1 signaling and stress response in yeast.

The paper analyzes gene expression patterns in yeast colonies to understand how genetic and spatial factors influence colony structure development.

The paper analyzes 3,034 Saccharomyces cerevisiae genomes to characterize population structure, revealing 93% species diversity and ecological clustering patterns.

Saccharomyces Genome Database released two S288C annotation updates (R64.4.1, R64.5.1) adding ncRNAs, ORFs and uORFs, overhauled YeastPathways, and expanded search, GFF and web features.

The paper introduces an AID library for on-demand protein depletion in yeast, enabling systematic study of protein function and uncovering new roles in cell cycle and mitochondrial processes.