Viral-associated cancers and disorders

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

This study shows that a replication-dead murine gammaherpesvirus lacking pathogenesis genes can protect against wild-type virus infection by inducing neutralizing antibodies and CD8 T-cell responses.

Reevaluating the Association Between Epstein-Barr Virus (EBV) and Breast Cancer in the United States

This paper evaluates limitations in EBV detection protocols for breast cancer studies in the US, finding that many assays use outdated or mismatched sequences, potentially skewing results.

Glycoprotein K8.1 shapes KSHV liver and bone marrow tropism in the marmoset infection model

This study shows that glycoprotein K8.1 is critical for KSHV tissue tropism in marmosets, but not for initial infection.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

This study uses cryoET and deep learning to reveal structural differences in the tegument and envelope of EBV and KSHV virions compared to other herpesviruses.

Decoding critical targets and signaling pathways in EBV-mediated diseases using large language models

This study uses large language models to analyze EBV-related publications, identifying key antigens and pathways involved in EBV-mediated diseases and validating their roles in specific cancers.

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression

This study uses single-cell transcriptomics to analyze EBV lytic reactivation in B cells, revealing abortive, reprogrammed, and host shutoff states with distinct gene expression patterns.

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program

This study shows that WAPL suppresses LMP1 and LMP2A expression in EBV latency I by altering DNA looping and histone marks, preventing the transition to latency II.

MicroRNA-focused CRISPR/Cas9 Screen Identifies miR-142 as a Key Regulator of Epstein-Barr Virus Reactivation

The paper identifies miR-142 as a regulator of EBV reactivation through CRISPR/Cas9 screening and shows it suppresses SOS1/Ras/Raf/Mek/Erk signaling initiated by the BCR.

Combination of bortezomib and venetoclax targets the pro-survival function of LMP-1 and EBNA-3C of Epstein-Barr virus in post-transplant lymphoproliferative disorder

This paper shows that combining bortezomib and venetoclax kills PTLD cells by targeting EBV proteins LMP-1 and EBNA-3C through proteasome inhibition and Bcl-2 suppression.

Incorporation of Epstein-Barr viral variation implicates significance of LMP1 in survival prediction and prognostic subgrouping in Burkitt lymphoma

The paper identifies EBV variants, particularly in LMP1, associated with survival in Burkitt lymphoma and defines prognostic subgroups based on these features.

Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein

The paper uses electron microscopy to map DNA-binding sites of KSHV RTA protein and identifies its oligomeric states when bound to viral DNA.

Herpesvirus infections eliminate safeguards against breast cancer and its metastasis: comparable to hereditary breast cancers

The paper shows EBV infections disable breast cancer safeguards, leading to similar genetic and molecular patterns as hereditary breast cancers.

The viral packaging motor potentiates late gene expression in Kaposi's sarcoma-associated herpesvirus

The paper identifies ORF29 as a viral DNA packaging motor subunit that potentiates late gene expression in KSHV, linking transcription and packaging processes.

The EBNA2-EBF1 complex promotes oncogenic MYC expression levels and metabolic processes required for cell cycle progression of Epstein-Barr virus-infected B cells

This study identifies how EBNA2 interacts with EBF1 to drive MYC expression and metabolic processes necessary for cell cycle progression in EBV-infected B cells.

Regulation of EBNA1 Protein Stability by PLOD1 Lysine Hydroxylase

This study identifies PLOD1 as a post-translational regulator of EBNA1 protein stability and function in EBV latency, showing that PLOD1 depletion reduces EBNA1 levels and inhibits viral replication and episome maintenance.

The influence of human genetic variation on Epstein-Barr virus sequence diversity

The paper investigates how human genetic variation influences Epstein-Barr virus (EBV) sequence diversity by analyzing paired viral and human genomic data from HIV-coinfected individuals.

Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

This study identifies a genetic variant near CXCL12 associated with increased susceptibility to HIV-related non-Hodgkin lymphoma.

Epstein Barr virus genomes reveal population structure and type 1 association with endemic Burkitt lymphoma

The paper analyzes EBV genomes from eBL patients and controls in Kenya, finding type 1 EBV is more common in patients and identifying genetic variants associated with eBL.

B Cell Receptor-Responsive miR-141 and viral miR-BART9 promote Epstein-Barr Virus Reactivation Through FOXO3 Inhibition

The paper identifies miR-141 and EBV miR-BART9 as regulators of B cell reactivation through FOXO3 inhibition, linking BCR signaling to lytic replication in EBV.

Conserved CxnC motifs in Kaposi’s sarcoma-associated herpesvirus ORF66 are required for viral late gene expression and mediate its interaction with ORF34

This paper identifies conserved CxnC motifs in KSHV ORF66 essential for its interaction with ORF34 and late gene expression.

Genome sequencing analysis identifies high-risk Epstein-Barr virus subtypes for nasopharyngeal carcinoma

The paper identifies two EBV variants in BALF2 associated with increased NPC risk through genome sequencing and association studies in China.

The interaction between ORF18 and ORF30 is required for late gene expression in Kaposi’s sarcoma-associated herpesvirus

This study identifies the critical role of the ORF18-ORF30 interaction in KSHV late gene expression through mutational analysis.

(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus lytic replication involves latent membrane protein 1-mediated MAPK signaling pathways

This study shows that LMP1 promotes EBV reactivation via MAPK signaling and that EGCG inhibits this process by suppressing LMP1-mediated signaling.

Kaposi’s sarcoma-associated herpesvirus ORF68 is a DNA binding protein required for viral genome cleavage and packaging

This study identifies KSHV ORF68 as a DNA-binding protein essential for viral DNA cleavage and packaging, revealing its role in capsid formation and infectious virion production.

Cataloguing Over-Expressed Genes In Epstein Barr Virus Immortalized Lymphoblastoid Cell Lines Through Consensus Analysis Of PacBio Transcriptomes Corroborates Hypomethylation Of Chromosome 1