Viral-associated cancers and disorders

Epstein-Barr Virus Encoded lncRNAs Control the Viral Lytic Switch

This study identifies viral lncRNAs that regulate EBV reactivation by interacting with CTCF and modulating enhancer-promoter looping.

HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins

This study uses spatial transcriptomics to show that EBV+ HIV-associated NHLs have distinct tumor microenvironment features, including immunosuppressive pathways and spatial organization similar to lymphoid tissues.

The spatial landscape of infectious mononucleosis tonsils

This study creates the first multiomic single-cell spatial atlas of palatine tonsils in infectious mononucleosis, revealing EBV's epithelial tropism and immunosuppressive microenvironment.

Single-Cell Profiling of HDAC Inhibitor-Induced EBV Lytic Heterogeneity Defines Abortive and Refractory States in B Lymphoblasts

This study uses single-cell RNA sequencing to analyze the effects of HDAC inhibitors on EBV lytic reactivation in B lymphoblasts, identifying abortive and refractory states.

A high-resolution, unbiased analysis of the cellular immune response to Epstein-Barr virus

This study performs a single-cell transcriptomic analysis of EBV-responsive lymphocytes in healthy and immunodeficient individuals, identifying key immune mechanisms and potential therapeutic targets.

Virally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection

This study shows that viral IL-6 (vIL-6) and human IL-6 work together to influence cytokine expression and immune responses during KSHV infection.

Genome-wide mapping of EBV-induced genomic variationsidentifies the role of MUC19 in EBV latency

This study maps EBV-induced genomic variations and identifies MUC19 as an oncogenic factor promoting latency through mTOR activation.

Human RIG-I deficiency confers susceptibility to Kaposi Sarcoma via loss of latency control

This study identifies RIG-I deficiency as a cause of classic Kaposi sarcoma by impairing control of KSHV infection and reactivation.

Characterization of the Kaposi's sarcoma-associated herpesvirus terminase complex component ORF29

This study identifies ORF29 as a critical component of the KSHV terminase complex, essential for capsid formation and TR cleavage, and shows it interacts with itself and ORF7.

Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi's Sarcoma

This paper presents a spatial single-cell atlas of Kaposi's sarcoma, identifying CD34+ progenitor lymphatic endothelial cells as primary targets of KSHV and revealing mechanisms of tumor progression and immune modulation.

A direct RNA-seq-based EBV Latency Transcriptome Offers Insights into the Biogenesis of EBV Gene Products.

This paper uses long-read RNA-seq to analyze EBV transcriptomes in LCLs, identifying new splicing variants, polyA sites, and transcript structures, and provides tools and annotations for future studies.

Epstein-Barr Virus Selects for Stem Cell Lineages in Breast Cancer and Normal Tissues

The paper identifies EBV-associated methylation patterns in breast cancer and normal tissues that align with stem cell differentiation pathways, suggesting EBV contributes to cancer susceptibility through epigenetic changes.

Population-scale sequencing resolves correlates and determinants of latent Epstein-Barr Virus infection

The paper uses population-scale whole genome sequencing to identify EBV DNA as a biomarker for respiratory, autoimmune, and cardiovascular diseases and identifies genetic determinants of EBV persistence.

Insights into the Absence of Lymphoma Despite Fulminant Epstein-Barr Virus Infection in Patients with XIAP Deficiency

This study investigates why XLP-2 patients, with XIAP deficiency, avoid EBV-driven lymphoma despite severe EBV infection, finding that XIAP loss impairs EBV-induced B-cell outgrowth and promotes apoptosis.

Oncogenic virus hijacks SOX18 pioneer function to enhance viral persistence

This study shows KSHV uses SOX18 to maintain viral episomes in LECs by enhancing chromatin accessibility.

Epstein-Barr Virus Latent Membrane Protein 1 Subverts IMPDH pathways to drive B-cell oncometabolism

This study identifies LMP1-driven metabolic reprogramming in B-cells, showing that IMPDH inhibition sensitizes EBV-transformed cells to apoptosis, suggesting therapeutic targets for LMP1-driven lymphomas.

Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta

The paper investigates EBNA-1 specific antibodies in IM patients, finding persistent functional antibodies with cross-reactivity to CRYAB and association with MS risk alleles.

Heat shock factor 2 positively regulates oncogenic herpesvirus gene expression by remodeling the chromatin landscape

This study shows HSF2 promotes gamma-herpesvirus lytic gene expression by altering chromatin structure at key viral promoters.

Caspase Cleavage of Kaposi Sarcoma-Associated Herpesvirus Proteins: A role for K5 in Preventing Caspase-Mediated Cell Death during Lytic Replication

This study identifies K5 as a KSHV protein cleaved by caspases during lytic replication, which helps protect infected cells from apoptosis.

Endothelial cells stably infected with recombinant Kaposi's sarcoma-associated herpesvirus display distinct viscoelastic and morphological properties

This study quantifies morphological and mechanical changes in endothelial cells infected with KSHV, identifying potential diagnostic and therapeutic markers.

Single-Cell Transcriptomic Analysis of Kaposi Sarcoma

This study uses single-cell RNA sequencing to analyze Kaposi Sarcoma tumors and blood samples, identifying KSHV-infected cell types and their biomarkers, and showing changes with therapy.

Studies on Gene Enhancer with KSHV mini-chromatin

This study investigates how KSHV terminal repeats (TR) function as enhancers by regulating BRD4 recruitment and promoter activation during viral reactivation.

The Elevated Expression of ORF75, a Lytic KSHV Gene, in Kaposi Sarcoma Lesions is Driven by a GC-rich DNA cis Element in its Promoter Region

This study identifies a GC-rich cis element in the ORF75 promoter of KSHV that drives its constitutive expression in endothelial and epithelial cells, contributing to its high expression in Kaposi sarcoma lesions.

Long-read Transcriptomics of Caviid Gammaherpesvirus 1: Compiling a Comprehensive RNA Atlas

This paper uses long-read RNA sequencing to create a comprehensive transcriptomic atlas of Caviid Gammaherpesvirus 1, revealing its transcriptome and regulatory mechanisms.

Spatiotemporal analysis of de novo KSHV infection using Crispr/Cas9-based 3D live cell imaging at single episome resolution

This study develops a CRISPR/Cas9-based 3D live cell imaging system to track KSHV episomes in real-time, revealing their spatiotemporal dynamics during infection.

Polycomb group proteins protect latent Kaposi sarcoma-associated herpesvirus from episome clearance and HUSH-dependent chromatin silencing

This study shows that Polycomb group proteins maintain KSHV latency by repressing viral gene expression and protecting episomes from HUSH-dependent silencing.

Differential EBV protein-specific antibody response between responders and non-responders to EBVSTs immunotherapy

The paper identifies differential EBV protein-specific antibody responses between responders and non-responders to EBVST immunotherapy, suggesting these antibodies could predict clinical outcomes.

E2F1 Suppresses EBV Lytic Reactivation through Cellular and Viral Transcriptional Networks

This study identifies E2F1 as a suppressor of EBV lytic reactivation by regulating transcriptional networks involving BZLF1 and c-Myc.

Unmasking Epstein-Barr Role in Gastric Carcinogenesis: A Gene Expression Approach to Virus-Positive Tumors

This study uses RNA-seq to analyze gene expression in EBV-positive and EBV-negative gastric cancer samples, identifying differentially expressed genes and viral gene activity associated with tumor progression.

Host microRNA-31-5p represses oncogenic herpesvirus lytic reactivation by restricting the RNA-binding protein KHDRBS3-mediated viral gene expression

The paper identifies miR-31-5p as a regulator of KSHV lytic reactivation by targeting KHDRBS3, reducing viral gene expression and infectious virion production.