Retinal Development and Disorders

The paper shows that a single Musashi gene allele is sufficient to maintain photoreceptor function and splicing in mice.

The paper generates an Igfn1iCre knock-in mouse line to study type-7 bipolar cells during development and confirms Igfn1 expression in these cells and other retinal types.

The paper uses single-cell RNA sequencing to characterize cellular heterogeneity in RGC-enriched retinal organoids and shows marker-based assessments may overestimate RGC identity.

This study shows that disrupting the internal limiting membrane enhances the survival and functional integration of transplanted human retinal ganglion cells in the retina.

This study provides a time-resolved transcriptomic reference for porcine retinal explants cultured ex vivo, revealing gene expression changes and biological processes over 10 days.

The paper investigates backpropagation in primate foveal cones and finds it effective despite cell structure, but unlikely to influence phototransduction.

This study investigates the role of LRIT3 domains in synaptic assembly and retinal function, showing that the LRR and IG domains are critical for TRPM1 localization and signalplex function in retinal bipolar cells.

The paper generates spatial proteomic atlases of human and mouse retinas using IBEX, revealing protein expression patterns and structural features of retinal cell populations.

The paper compares two Rax-Cre transgenic drivers in mice to evaluate their Cre activity in the embryonic eye and extra-ocular tissues.

The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.

This study shows that oxidative DNA damage causes photoreceptor loss in NMNAT1-related retinal degeneration and that NAC treatment reduces damage and preserves vision.

The paper develops inducible CreERT2 mouse lines to characterize specific bipolar cell subtypes in the mouse retina and identifies their lineage and expression patterns.

This study shows that blocking apoptosis in retinal organoids increases RGC survival but delays their development, highlighting apoptosis's role in regulating RGC quantity and dynamics.

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

The paper shows rod photoreceptors control the dynamic switch of ON and OFF polarity in cone-signaling neurons through EAAT5 glutamate transporters.

The paper investigates retinal spheroid layer formation by analyzing Rax::GFP-positive retinal progenitor cells, revealing sequential WNT signaling and environmental factors in retinal development.

This study demonstrates that gene therapy using AAV vectors can rescue retinal degeneration in PROM1-IRD patient and mouse models by restoring PROM1 expression and photoreceptor structure.

This study shows that photodisrupting the inner limiting membrane improves the engraftment of stem-cell derived retinal ganglion cells in retinal explants.

This study shows that the PRPF8-Y2334N variant causes photoreceptor defects in human neural retina cells without affecting the retinal pigment epithelium.

This study shows deep-sea fish larvae use a hybrid cone-rod photoreceptor type for vision in dim light, revealing an alternative developmental pathway for vertebrate vision.

This study shows Tbx2, Tbx3, and Tbx5 regulate each other and early patterned genes in chick retinal development, affecting photoreceptor distribution and the rod-free zone.

This paper tests AAV8/Best1-Nrf2 gene therapy in rodent models of oxidative stress, showing protection of retinal cells and preservation of visual function.

This study investigates PIKfyve's role in photoreceptors and retinal pigment epithelium, finding that its loss causes structural and functional defects in these tissues.

This study identifies two Tbr2-dependent transcription factors, Irx1 and Tbx20, that regulate distinct pathways for the formation and maintenance of six ipRGC subtypes in mice.

This paper uses deep learning to predict tissue outcomes in retinal organoids before they are visually discernible, improving understanding of developmental trajectories.

This study revives and sustains light signal transmission in postmortem human retinas and develops tools for drug testing and ischemia-reperfusion modeling.

The paper identifies cxcl18b-defined transitional states in zebrafish Muller glia that drive cell-cycle re-entry after retinal injury, with nitric oxide playing a key regulatory role.