Parasites and Host Interactions

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

The paper genotypes Schistosoma haematobium eggs from Nigerian communities to identify interspecific hybrids between S. haematobium, S. bovis, and S. curassoni, finding mitonuclear discordance and hybrid diversity in both pastoral and non-pastoral regions.

This study identifies A20 as an essential myeloid factor for inducing type-2 immune responses against Trichuris muris, with its loss leading to chronic infection and inflammation.

This study shows that relocating waterfowl broods reduces snail infection by an avian schistosome, lowering swimmers itch cases in lakes.

The paper reanalyzes a GWAS to show that a single locus on chromosome 3 determines praziquantel response in Schistosoma mansoni, rather than two loci.

This study identifies a cation current activated by praziquantel in Schistosoma mansoni neuronal tissue, matching the properties of TRPMPZQ.

This study shows that Mmp17-deficient mice have increased goblet cell effector genes and resistance to Trichuris muris infection without changes in traditional immune modulators.

The paper investigates the role of carbonic anhydrase inhibition in Biomphalaria glabrata snails infected with Schistosoma mansoni, showing that aspirin analogs can reduce CA expression in susceptible snails.

This study applies CRISPR interference to repress SmfgfrA in Schistosoma mansoni, showing reduced transcription, protein expression, and immune response, with durable effects on parasite development and host granuloma formation.

The paper tests if the PTC2 region explains resistance differences between two Biomphalaria glabrata strains to Schistosoma mansoni, but finds the BS90 haplotype increases susceptibility instead.

This study presents the first population genomics analysis of Trichuris trichiura using whole-genome sequencing of ancient and modern samples, revealing genetic structure and admixture patterns across human and primate hosts.

This study identifies parasite-specific neural adaptations in Strongyloides stercoralis that enable temperature-driven host seeking.

This study compares the proteomes of two penetration gland types in avian schistosome cercariae using laser microdissection and MS, identifying differences in protein composition and abundance.

This study uses proteomics to identify molecular changes in mouse bladders infected with Schistosoma haematobium eggs, revealing enriched biological processes linked to pathology.

This paper identifies and characterizes SmNAGAL, a glycosyl hydrolase in Schistosoma mansoni, showing its role in coordinating parasite movement and egg production, suggesting it as a potential target for new anthelmintic drugs.

The paper identifies a transient receptor potential channel (Sm.TRPMPZQ) as the genetic basis for variation in praziquantel response in Schistosoma mansoni.

This study identifies SmHDAC8 as involved in cytoskeleton organization through its interaction with SmRho1 isoforms in Schistosoma mansoni, showing acetylation of SmRho1 and disruption of actin cytoskeleton upon SmHDAC8 inhibition.

The paper investigates how PIWI and retrotransposon nimbus interact to modulate resistance to Schistosoma mansoni in Biomphalaria glabrata snails through epigenetic mechanisms.

This study analyzes the transcriptome of Schistosoma mansoni developing eggs to identify genes involved in pathogenesis and life cycle progression.

This study identifies five QTLs associated with cercarial production in Schistosoma mansoni using linkage analysis, explaining 28.56% of phenotypic variation.

The paper introduces a web-based tool for analyzing RNA-seq data from Strongyloides species, enabling on-demand gene expression analysis without coding experience.

This paper uses CRISPR/Cas9 to edit the acetylcholinesterase gene in Schistosoma mansoni eggs, resulting in reduced AChE activity and decreased granuloma size in mice.

This study creates a single-cell RNA sequencing atlas of the early intra-mammalian stage of Schistosoma mansoni, identifying gene expression profiles and validating cell markers.

This study performs genome assembly and transcriptome analysis of Microtus fortis to understand its resistance to Schistosoma japonicum infection, revealing differences in immune response timing and effectiveness compared to mice.

The paper uses genomic data from Guinea worm infections in humans and dogs to show they originate from the same population, indicating transmission between species and a population bottleneck.

This paper uses CRISPR/Cas9 to knockout the BgAIF gene in Bge cells, showing reduced adherence to Schistosoma mansoni sporocysts.

This study uses CRISPR-Cas9 to induce deletions in the SULT-OR gene of Schistosoma mansoni, showing potential for oxamniquine resistance but limited mRNA knockdown due to low mutation frequency.

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.

This study examines the transcriptomic responses of Biomphalaria pfeifferi and Schistosoma mansoni to niclosamide exposure, revealing differential gene expression patterns in snails and sporocysts under various stress conditions.