Wound Healing and Treatments

Hypoxia Promotes Wound Healing via Dynamical-Mechanical Balance and Adhesion Remodeling

This study shows hypoxia accelerates wound healing by altering cell-cell and cell-matrix adhesion dynamics through DSG2 downregulation and ITGB3 biphasic regulation.

Wound healing and angiogenic profiling of dermal endothelial cells isolated from people with type 2 diabetes.

This study examines dermal endothelial cells from people with type 2 diabetes, finding they have altered migratory, angiogenic, and gene expression profiles compared to healthy cells.

A Novel Monocyte-derived Antigen Presenting Cell-T regulatory Cell Axis Contributes to Skin Wound healing and is Impaired in Diabetic Mice

Electrostatically Assembled Layer-by-Layer Plasmonic Implant for Combination Therapy against Multidrug-Resistant Chronic Wound Biofilms

This paper develops a layer-by-layer plasmonic implant for combination therapy against multidrug-resistant chronic wound biofilms, showing effective bacterial elimination and controlled drug release.

Genotypic and functional characterization of fibroblasts derived from pressure sores

This study characterizes the genotypic and functional differences between healthy and pressure sore-derived fibroblasts, revealing reduced ECM protein expression and impaired myofibroblast differentiation.

UT-018 Accelerates Wound Repair and Hair Follicle Regeneration in Murine Models

UT-018, a stem cell chemoattractant, accelerates wound repair and hair follicle regeneration in mice by enhancing tissue repair processes and inducing anagen-phase transition.

Composite biomaterials of polyelectrolyte complex micelle nanoparticles in hyaluronic acid gels enable local, targeted miR-92a inhibition and enhanced angiogenesis in diabetic wound repair

This paper develops a composite biomaterial combining polyelectrolyte complex micelles with hyaluronic acid gels to deliver miR-92a inhibitors, enhancing angiogenesis and accelerating wound healing in diabetic mice.

Reparative and regenerative immature neutrophil-like population derived from HL-60 cells

This study differentiates HL-60 cells into immature neutrophil-like cells using DMSO and D3, showing their regenerative potential in corneal wound healing.

Macrophage metabolism directs regenerative versus fibrotic healing through BMP signaling in the mouse digit tip

This study identifies a regeneration-specific macrophage population in mouse digit tip regeneration that uses BMP signaling and a unique metabolic profile to drive bone formation, absent in scar-forming injuries.

Enterococcus faecium colonization and persistence in a model of diabetic wound infection

This study uses a diabetic mouse model to show that Enterococcus faecium persists in wounds due to impaired clearance and altered immune responses compared to non-diabetic mice.

Investigation of sterile hydrogels as topical vehicles for APOSEC™, a stressed peripheral blood mononuclear cell secretome for the treatment of poorly healing wounds

This study evaluates a hydrogel-based delivery system for APOSEC™ in wound healing, finding improved release but non-uniform mixing and no significant efficacy difference compared to a benchmark gel.

Multi-omics analysis of type II diabetic wound healing reveals CD44-mediated immune cell crosstalk dysfunction in mice and humans

Diminished and altered cellular senescence response in delayed wound healing of aging

This study shows that aging reduces and alters the senescence response in wound healing, leading to delayed repair due to fewer and less functional senescent cells.

Transcriptional regulators predicted to drive macrophage dysregulation during impaired wound healing in diabetic mice

This study identifies transcriptional regulators driving macrophage state transitions in diabetic wound healing using scRNA-seq and computational methods.

Oxygen-Releasing Hydrogel Patches Restore pH Balance and Support Cell Survival in Acidic Oral Wound Models

This paper develops a hydrogel patch that releases oxygen and buffers acidity in oral wound models, improving cell viability and pH balance.

Schwann cell dysfunction contributes to diabetic wound pathology which is partially ameliorated by oncostatin M treatment

This study shows that Schwann cell dysfunction contributes to diabetic wound healing impairment and that oncostatin M treatment partially improves wound repair in diabetic mice.

Exercise-induced Sweat Promotes Wound Healing in Diabetic Foot Ulcers

This study shows that exercise-induced sweat promotes wound healing in diabetic foot ulcers by enhancing re-epithelialization, collagen deposition, and angiogenesis in a mouse model.

DeepMapper: Attention-Based AutoEncoder for System Identification in Wound Healing and Stage Prediction

This paper proposes a deep learning-based control framework for wound healing that accelerates closure by 17.71% in simulations and 40% in vivo.

Exudate-Guided Janus Trilayer Bioelectronic Dressing for Multiplexed Sensing and Therapy of Chronic Wounds

This paper introduces a bioelectronic dressing that senses and treats chronic wounds through real-time biochemical monitoring, drug release, and electrical stimulation.

THE COMPARATIVE STUDY OF THE EFFECT OF LOW-INTENSITY BROADBAND AND LOW-INTENSITY PULSED ULTRASOUND ON THE AMPUTATIONAL MODEL OF WOUND

This study compares the effects of ultra-wideband low-intensity mechanical waves (UMUS) and low-intensity pulsed ultrasound (LIPUS) on wound healing in a rat amputation model, finding UMUS more effective in reducing wound size and promoting tissue repair.

Autologous skin cell suspensions established by the VeritaCell method accelerate healing and suppress scarring-associated cutaneous thickening in a rat wound model in vivo

The paper evaluates the in vivo efficacy of VeritaCell-derived autologous skin cell suspensions in a rat wound model, showing accelerated healing and reduced scarring.

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs

This study shows that Smad7-based biologic treatment accelerates diabetic wound healing in mice and pigs by targeting keratinocytes and neutrophils, reducing inflammation and promoting tissue repair.

Modes of programmed macrophage cell death govern outcome of cutaneous wound healing

This study shows that different modes of macrophage cell death affect wound healing outcomes, with necroptosis impairing repair and apoptosis promoting better tissue recovery.

Osteopontin promotes lesion repair during Staphylococcus aureus skin infections

This study identifies osteopontin (OPN) as a critical mediator of tissue repair during Staphylococcus aureus skin infections by analyzing single-cell transcriptomics in a murine model.

An Engineered Living Material with pro-angiogenic activity inducible by near-infrared light

The paper develops an engineered living material that uses NIR light to release a pro-angiogenic peptide, promoting capillary network formation in endothelial cultures.

Unraveling the Regenerative Proteomic Signature of Helix aspersa's Slime in Human Dermal Fibroblasts by Data-driven Proteomics Approach

This study uses proteomics to show that snail slime induces redox modulation, controlled apoptosis, and enhanced migration in human dermal fibroblasts, supporting its regenerative potential.

Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

A multidisciplinary approach for the study of age-dependent expression patterns in porcine experimental wounds

This study uses a multidisciplinary approach to identify age-dependent expression patterns in porcine experimental wounds to improve objective wound age estimation in forensic cases.

Bioabsorbable Magnesium Metal ScaffoldsImprove Dermal Wound Healing and Tissue Regeneration

This study evaluates bioabsorbable magnesium wires in a murine wound model, showing improved granulation tissue, reduced inflammation, and enhanced neovascularization.