Extracellular vesicles in disease

The paper develops a tool to track exosomal cargoes by labeling Rab7 partners using proximity labeling and mass spectrometry.

The paper describes a method to isolate and characterize lipoprotein classes in plasma, revealing unique lipidomic, proteomic, and small RNA signatures for each class.

This paper demonstrates that extracellular vesicles carrying ARG1 can restore enzyme activity and extend lifespan in a mouse model of ARG1-D.

This study develops a microfluidic device to enrich pancreatic cancer-derived extracellular vesicles based on charge, linking KRAS status to EV secretion and surface charge.

This study shows that loss of ovarian hormones alters EV nucleic acid content and skeletal muscle metabolism during acute exercise in female rats.

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

This study shows that platelet-derived biomaterials reduce mitochondrial dysfunction in neuronal injury models by restoring ATP production, reducing ROS, and improving mitochondrial structure and function.

This paper demonstrates that lipid nanoparticle-delivered miR-187 reduces inflammation and improves cardiac function in sepsis models.

This study identifies mechanically-activated osteocyte-derived extracellular vesicles and miR-150-5p as key regulators of osteoclastogenesis and potential therapeutic targets for skeletal diseases.

The paper shows BeWo-derived extracellular vesicles reduce IL-6Rα on CD4+ T cells via miRNAs, altering the IL-6 pathway and T cell function in vitro and correlating with pregnancy-associated IL-6R downregulation.

This study identifies stage-specific molecular cargo in Schwann cell-derived extracellular vesicles and shows their roles in peripheral nerve regeneration.

The paper develops a method to specifically capture prostate-derived extracellular vesicles from urine, enabling transcriptomic analysis and improving specificity for prostate cancer detection.

The paper identifies an exosomal miRNA signature related to EMT that predicts prognosis in hepatocellular carcinoma with moderate accuracy.

VDisk is a microfluidic platform for automated, label-free EV isolation from plasma, showing improved reproducibility and EV/contaminant ratios compared to SEC.

This study shows syntenin facilitates ECM degradation by controlling MT1-MMP secretion in sEV and invadopodia formation in TNBC cells.

This study introduces a metabolic labeling method using 5-EU and UCK2 overexpression to track RNA in donor cells, EVs, and recipient cells, enabling visualization and quantification of EV-RNA transfer.

This paper develops an analytical toolbox and scalable downstream processing workflow for high purity extracellular vesicles from mesenchymal stromal cells, using orthogonal methods to improve reproducibility and purity.

This study quantitatively characterizes the lipid composition of extracellular vesicles from multiple cell lines to identify biomarkers and inform EV engineering.

This study compares EV transcriptomics, proteomics, and cfDNA methylation for detecting colorectal neoplasia, finding EV transcriptomics most sensitive for advanced adenomas and CRC.

The paper identifies a dual-domain mechanism in the Flower protein that coordinates extracellular vesicle-mediated fitness selection and cell-intrinsic survival in astrocytes, with implications for Alzheimer's disease.

This study shows that Panax notoginseng-derived extracellular vesicles deliver miRNAs to neurons, reducing ischemic injury by modulating stress responses and mitochondrial function.

The paper develops a targeted RNA capture method to enhance detection of long RNAs in EVs from human biofluids, revealing biofluid-specific transcriptomes and splicing patterns.

This paper demonstrates that 3D-printed scaffolds encapsulating red blood cell-derived extracellular vesicles can deliver sncRNAs effectively for CNS therapy.

This study identifies nSMase2-generated exosomes as a mechanism for adipocyte LPL secretion and transfer to endothelial cells via GPIHBP1.

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance angiogenesis in a pre-clinical model, suggesting their potential as a pro-angiogenic nanotherapeutic for bone repair.

This study profiles urinary exosomal miRNAs in pregnant women with SLE and identifies altered miRNAs linked to metabolic, immune, and senescence pathways, suggesting their potential as non-invasive biomarkers for pSLE complications.

This study identifies KCa3.1 channels as a target for enhancing immune responses in HNSCC by showing exosomes suppress CD8 T cell function through Ca2+ signaling disruption.

This study demonstrates that nanoalgosomes from Tetraselmis chuii protect skin cells from UVB damage, reduce oxidative stress, and modulate melanogenesis for anti-aging and depigmentation.

This study uses AFM to analyze how the tumor microenvironment affects the physical properties of MSC-derived exosomes, revealing changes in morphology and mechanics that may impact their function.