Viral gastroenteritis research and epidemiology

This study examines the formation of viroplasm-like structures (VLS) by co-expressing NSP5 and NSP2 across Rotavirus species A-J, finding species-specific VLS morphology and self-oligomerization properties of NSP5.

This study identifies di-arginine motifs in the N-terminal domain of astrovirus nsP1a that mediate ER retention and replication complex formation.

This study identifies that the Norovirus NS1/2 protein enhances glutaminolysis to support viral replication in macrophages.

This paper identifies three neutralizing monoclonal antibodies against HAstV-VA1 and maps their epitopes, revealing four antigenic sites and immune pressure-driven mutations in a patient with encephalitis.

This study shows that BA-dependent human norovirus strains require S1PR2 for infection, while BA-independent strains do not, suggesting S1PR2 as a potential therapeutic target.

This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.

This study shows that blocking P2Y1 receptors reduces rotavirus-induced diarrhea and viral shedding in mice, suggesting P2Y1 signaling promotes disease.

This study identifies mutations in murine norovirus that enhance replication in human cells, revealing post-entry restrictions in addition to receptor expression.

The paper reports a novel calicivirus found in an Indian bovine calf and highlights its divergence from known Neboviruses.

The paper develops a reverse genetics system to produce a porcine rotavirus expressing a fluorescent reporter, enabling vaccine development and antigen expression.

This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

The paper presents the near-atomic structure of the aquareovirus core and reveals structural differences that suggest a mechanism for transcription initiation in multilayered reoviruses.

The paper uses molecular dynamic simulations to analyze VP1 mutants of Rotavirus group A, revealing structural changes that may affect viral replication and vaccine effectiveness.

This paper identifies and analyzes two types of neutralizing Nanobodies against murine norovirus, revealing structural vulnerabilities in the capsid that could inform antiviral development.

The paper determines the in situ structure of rotavirus VP1 RNA-dependent RNA polymerase using local reconstruction, showing conformational changes during transcription and stochastic distribution of VP1 molecules.

The paper determines the cryo-EM structure of GII.4 norovirus VLPs and finds they exhibit T=4 symmetry, with structural and antigenic differences compared to T=3 VLPs.

This paper shows that a monoclonal antibody (10E9) blocks norovirus by competing with HBGA binding and neutralizes virus in cell culture, despite antigenic drift in GII.4 variants.

This study uses real-time metagenomic sequencing during a norovirus outbreak to identify transmission clusters and ongoing viral shedding in a hospital setting.