Aortic aneurysm repair treatments

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm

This study evaluates the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm compared to current strategies.

Myeloid-Specific Thrombospondin-1 Deficiency Exacerbates Aortic Rupture via Broad Suppression of Extracellular Matrix Proteins

This study shows that myeloid-specific thrombospondin-1 deficiency increases aortic rupture risk by suppressing extracellular matrix proteins and inflammation in aneurysms.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm

This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.

Could Metformin use reduce abdominal aortic aneurysm risk? A Mendelian randomisation study using known Metformin targets

This study uses Mendelian randomisation to investigate a causal link between Metformin use and reduced abdominal aortic aneurysm risk, finding a statistically significant association.

Integrative analysis of multi-omics and machine learning highlighted an m6A-related mRNA signature as a robust AAA progression predictor

The paper develops an m6A-related mRNA signature using multi-omics and machine learning to predict AAA progression and identifies FKBP11 as a key gene.

NRF2 Regulates Contractile Vascular Smooth Muscle Cells Phenotypic Switching In Abdominal Aortic Aneurysm

This study shows NRF2 inhibits abdominal aortic aneurysm (AAA) development by maintaining contractile vascular smooth muscle cell (VSMC) phenotype through miRNA145 regulation.

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target

This study identifies 144 genetic loci associated with abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target through Mendelian Randomization and pre-clinical validation.

Modeling of microRNA-derived disease network repurposes methotrexate for the prevention and therapy of abdominal aortic aneurysm in mice

The paper models a microRNA-derived disease network to identify methotrexate as a potential therapy for abdominal aortic aneurysm in mice.

GSDMD Deficiency Protects Against Aortic Rupture

This study shows that GSDMD deficiency prevents aortic rupture in mice induced by AngII or BAPN, without affecting aortic dilation.

Integrated Plasma and Tissue Proteomics Reveals Attractin Release by Intraluminal Thrombus of Abdominal Aortic Aneurysms and Improves Aneurysm Growth Prediction in Humans

This paper identifies attractin as a biomarker for predicting abdominal aortic aneurysm growth using integrated plasma and tissue proteomics.

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort.

The paper investigates the association between genetic risk variants and clinical features of abdominal aortic aneurysms using a biobank cohort, finding a weak polygenic correlation with aneurysm diameter but no clear individual variant associations.

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.