Aortic aneurysm repair treatments

Neck Geometry and Shape Compactness as Additional Haemodynamic Modulators in Abdominal Aortic Aneurysms

This study develops a framework to analyze how AAA neck geometry and shape compactness affect haemodynamics, finding that neck diameter and sphericity are key determinants of wall shear stress.

Murine Abdominal Aortic Aneurysm Intraluminal Thrombus Composition and Structure

This study investigates the composition and structure of intraluminal thrombus in murine abdominal aortic aneurysms and its association with aneurysm expansion.

Protectin D1/GPR37 signaling enhances macrophage-dependent efferocytosis to attenuate experimental abdominal aortic aneurysm formation

This paper shows that PD1/GPR37 signaling in macrophages enhances efferocytosis, reducing inflammation and preventing AAA formation and rupture.

Early IKKb-dependent anabolic signature governs vascular smooth muscle cells fate and abdominal aortic aneurysm development

This study identifies an early IKKβ-dependent anabolic signature in vascular smooth muscle cells that drives abdominal aortic aneurysm development.

Vessel-on-Chip Model Of The Microcirculation In Abdominal Aortic Aneurysms

This study develops a patient-specific vessel-on-chip model of abdominal aortic aneurysms, showing preserved pathological features and pro-inflammatory responses in vitro.

Metformin Does Not Attenuate Angiotensin II-Induced Aortic Aneurysms in Low-Density Lipoprotein Receptor Deficient Mice

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

Global profiling of the proteome and acetylome in mice with abdominal aortic aneurysms

This study identifies potential therapeutic targets for abdominal aortic aneurysms by analyzing proteomic and acetylomic changes in a mouse model.

Pharmacologic Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

Endothelial miR-34a deletion guards against aneurysm development despite endothelial dysfunction

This study shows that deleting miR-34a in endothelial cells protects against aneurysm despite causing endothelial dysfunction.

Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture

This study delivers SOD2 mRNA via nanoparticles to mice with abdominal aortic aneurysms, reducing aneurysm expansion and rupture by enhancing antioxidant activity and modulating inflammatory pathways.

Evaluating the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm

This study evaluates the cost-effectiveness of polygenic risk score-stratified screening for abdominal aortic aneurysm compared to current strategies.

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm

This study shows platelets worsen AAA by promoting inflammation, ECM degradation, and osteopontin release, with platelet depletion reducing aneurysm growth.

Integrated Plasma and Tissue Proteomics Reveals Attractin Release by Intraluminal Thrombus of Abdominal Aortic Aneurysms and Improves Aneurysm Growth Prediction in Humans

This paper identifies attractin as a biomarker for predicting abdominal aortic aneurysm growth using integrated plasma and tissue proteomics.

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort.

The paper investigates the association between genetic risk variants and clinical features of abdominal aortic aneurysms using a biobank cohort, finding a weak polygenic correlation with aneurysm diameter but no clear individual variant associations.

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

The paper investigates the effect of the IL6R-Asp358Ala variant on AAA growth and evaluates IL-6 pathway blockade in mouse models, finding no significant growth rate reduction but improved survival with trans-signalling inhibition.