Ferroptosis and cancer prognosis

FerroEnrich: An Interactive web tool for computing Ferroptosis index and gene enrichment.

FerroEnrich computes ferroptosis index and gene enrichment using gene expression data through an interactive web tool.

Mechanism of RSL3-Induced Ferroptotic Cell Death in HT22 Cells: Contributing Role of Protein Disulfide Isomerase

This study shows RSL3 induces ferroptosis in HT22 cells by inhibiting TrxR1, activating PDI, and promoting NOS dimerization and NO accumulation.

Induction of Ferroptosis by an Amalgam of Extracellular Vesicles and Iron Oxide Nanoparticles Overcomes Cisplatin Resistance in Lung Cancer

This study develops ExoFeR, a system combining extracellular vesicles and iron oxide nanoparticles, to induce ferroptosis and overcome cisplatin resistance in lung cancer cells.

Ferroptosis susceptibility of melanoma cells: dependence on cell-type, acquired drug resistance, and medium composition

This study investigates melanoma cell susceptibility to ferroptosis and drug resistance using novel 3D culture models and medium compositions.

A machine learning and drug repurposing approach to target ferroptosis in colorectal cancer stratified by sex and KRAS

This paper identifies sex- and KRAS-specific ferroptosis differences in CRC and explores drug repurposing for KRAS mutant tumors using multi-omics data.

Strong Protection by Bazedoxifene Against Chemically-Induced Ferroptotic Neuronal Death In Vitro and In Vivo

This study shows that bazedoxifene inhibits PDI and protects against chemically-induced ferroptosis in neuronal cells both in vitro and in vivo.

Exploring the mechanisms and potential therapeutic targets of Ferroptosis Related Genes in ankylosing spondylitis

This study identifies 20 ferroptosis-related genes associated with ankylosing spondylitis using bioinformatics analysis and suggests targeting ferroptosis as a potential therapeutic strategy.

Overburdened Ferroptotic Stress Impairs Tooth Morphogenesis

The paper investigates the role of ferroptotic stress in tooth development using an ex vivo model, finding that excessive ferroptotic stress impairs tooth morphogenesis.

Identification of five characteristic ferroptosis-related genes as novel biomarkers for ischemic stroke using bioinformatic and machine learning strategies

The paper identifies five ferroptosis-related genes as biomarkers for ischemic stroke using bioinformatics and machine learning, showing their diagnostic value and associations with immune microenvironment changes.

Transcriptomic Enrichment of Ferroptosis-Related Gene ACSL4 in Advanced Hepatic Fibrosis/Cirrhosis: Bioinformatics Analysis and Experimental validation

This study identifies ACSL4 as a ferroptosis-related gene enriched in advanced liver fibrosis/cirrhosis, validated through bioinformatics and experimental methods.

Tumor microenvironment exploration and therapeutic target identification in bladder cancer based on Cuproptosis signature and chemotherapy-resistant model: results from bioinformatics and experimental validation

The paper identifies CYP26B1 and DLST as potential therapeutic targets in bladder cancer by analyzing cuproptosis signatures and chemotherapy resistance through bioinformatics and experimental validation.

DLST--a Cuproptosis-related Gene--is a Potential Diagnostic and Prognostic Factor for Clear Cell Renal Cell Carcinoma

The paper identifies DLST as a cuproptosis-related gene with diagnostic and prognostic value in clear cell renal cell carcinoma using TCGA data.

Pan-cancer genetic analysis of disulfidptosis-related gene set

This paper analyzes pan-cancer genomics and clinical associations of disulfidptosis-related genes across multiple cancer types, identifying key mutations, survival correlations, and potential therapeutic targets.

A novel cuproptosis-related gene signature for the prediction of liver cancer prognosis identified DLAT is a potential therapeutic target

Identification of differentially expressed pyroptosis-related genes in LUAD

The paper identifies differentially expressed pyroptosis-related genes in lung adenocarcinoma (LUAD) using data from GTEx and TCGA, finding two survival-differentiated clusters and ten genes with differential expression.

Pan-cancer analysis reveals the value of FDX1 as a novel biomarker in the prognosis and immunotherapy in human tumors

This study identifies FDX1 as a prognostic biomarker and potential target for immunotherapy across multiple cancers using pan-cancer analysis.

DHCR7 as a novel regulator of ferroptosis in hepatocytes

This study identifies DHCR7 as a regulator of ferroptosis in hepatocytes, showing that its inhibition suppresses ferroptosis through 7-DHC accumulation and highlights its therapeutic potential for liver diseases.

A Novel Prognosis Model based on Comprehensive Analysis of Pyroptosis-Related Genes in Breast Cancer

The paper develops a prognostic model for breast cancer using pyroptosis-related genes, identifying 4 genes associated with overall survival and validating its effectiveness through multiple analyses.

Epigenetic regulation of translation repression in ferroptosis, and a role of Alternative splicing and tRNA methylation.

This study investigates how transcription and translation repression affect ferroptosis induced by different inhibitors, revealing distinct protective and detrimental effects based on the type of inducer.

Establishment of a prognosis prediction model based on pyroptosis-related signatures associated with the immune microenvironment and molecular heterogeneity in clear cell renal carcinoma

The paper identifies two pyroptosis subtypes in ccRCC and constructs a prognosis prediction model based on pyroptosis-related risk scores.

Microglia ferroptosis is prevalent in neurodegenerative disease and regulated by SEC24B

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

Pyroptosis-related gene signatures can robustly diagnose skin cutaneous melanoma and predict the prognosis

The paper identifies 20 pyroptosis-related genes that can diagnose skin cutaneous melanoma and predict prognosis using machine learning and survival analysis.

Identification of the Novel Pyroptosis-Related Gene Signature in Patients with Esophageal Adenocarcinoma

The paper identifies a five-gene pyroptosis-related signature associated with survival in esophageal adenocarcinoma patients using TCGA data.

Identification and verification of the potential effect of therapeutic miRNA-mRNA pairs on ferroptosis in small cell lung cancer by bioinformatics analysis

The paper identifies and verifies potential therapeutic miRNA-mRNA pairs affecting ferroptosis in SCLC using bioinformatics analysis and validation with additional data.

A Compendium of Kinetic Cell Death Modulatory Profiles Identifies Ferroptosis Regulators

The paper identifies ferroptosis regulators using a compendium of kinetic cell death modulatory profiles from 1,833 small molecules.

Systematic identification of a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis

The paper identifies a nuclear receptor-enriched predictive signature for erastin-induced ferroptosis using gene expression analysis and pharmacogenomics datasets.