Ferroptosis and cancer prognosis

Labile iron pool dynamics do not drive ferroptosis potentiation in colorectal cancer cells

This study investigates the role of labile iron pool dynamics in ferroptosis in colorectal cancer cells and finds that exogenous iron supplementation reduces cell viability without measurable LIP expansion during ferroptosis.

Scutellarin inhibits ferroptosis by promoting cellular antioxidant capacity through regulating the Nrf2 signaling

Scutellarin suppresses RSL3- and erastin-induced ferroptosis in human HK-2 cells and mouse macrophages via Nrf2 upregulation, and reduces folic acid-induced kidney injury in mice.

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer

This study identifies GPX4 as a therapeutic target in LIMD1-deficient lung cancer by showing its role in ferroptosis susceptibility.

TATA box-based analysis reveals activation of growth programs in bladder cancer cells despite ferroptosis activation

The paper analyzes TATA box presence in gene expression data from bladder cancer cells undergoing ferroptosis, finding a high prevalence of TATA-less genes, suggesting growth promotion despite ferroptosis.

PDE10A Inhibition Disrupts Lipid Droplet Formation and Sensitizes Macrophages to Ferroptosis after LPS treatment

This study shows that PDE10A inhibition reduces lipid droplet formation and increases macrophage susceptibility to ferroptosis after LPS treatment.

Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis

The paper establishes a murine model of iron overload-induced hepatic ferroptosis and identifies a gene signature that predicts ferroptosis-related liver damage in both mice and humans.

A Dual Role for DGAT-mediated Lipid Droplet Biogenesis in Ferroptosis Regulation

This study shows that DGAT-mediated lipid droplet biogenesis regulates ferroptosis by modulating lipid distribution and membrane unsaturation, with context-dependent effects in different cancer cell types.

Dysregulation of cellular iron predisposes chemotherapy resistant cancer cells to ferroptosis

The paper shows chemoresistant cancer cells are vulnerable to ferroptosis due to iron dysregulation, despite varying ferroptosis sensitivity in untreated cells.

The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung

This study shows NUPR1 inhibition worsens oxidative stress, mitochondrial dysfunction, and metabolic imbalance in COPD, linking it to ferroptosis and disease progression.

Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cancer cells evaded by BACH1

This study shows that BACH1 maintains labile iron levels in HNSCC cells, preventing metabolic cell death and enabling proliferation, and that BACH1 inhibition enhances the effect of tipifarnib.

FMO4 drives lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and hindering ferroptosis

This study identifies FMO4 as a driver of lung adenocarcinoma by stabilizing the MAT2A/MAT2B complex and inhibiting ferroptosis.

Myeloid FtH Regulates Macrophage Response to Kidney Injury by Modulating Snca and Ferroptosis

This study shows that myeloid FtH deficiency worsens kidney injury by promoting ferroptosis through Snca and Spic, linking iron trafficking to macrophage dysfunction.

Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation

This study shows that macrophage ferroptosis impairs Aspergillus killing in lung transplant recipients, increasing fungal infection risk.

Assembling Ruthenium Complexes to Form Ruthenosome Unleashing Ferritinophagy-mediated Tumor Suppression

This paper introduces ruthenosomes, engineered ruthenium complexes that induce ferroptosis by enhancing ROS levels and activating ferritinophagy, effectively suppressing colorectal tumor growth.

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke

This study shows that ATM inhibition with AZD1390 reduces ferroptosis and neuronal death in ischemic stroke models.

Patient-Specific Pharmacogenomics unveils xCT Regulation Pathways in Colon Cancer

This study identifies xCT regulation pathways in colon cancer using patient-specific models and reveals potential therapeutic targets for chemotherapy resistance.

Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer

This study identifies two subtypes of colon cancer based on ferroptosis and cuproptosis-related genes, develops a prognostic signature, and evaluates its clinical utility and therapeutic implications.

VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis

Regulation of fatty acid oxidation involved in high altitude hypoxia induced cardiomyocyte ferroptosis via the SIRT1-PPARα-GPX4 signaling pathway

This study identifies the SIRT1-PPARα-GPX4 pathway as a therapeutic target for high-altitude hypoxia-induced cardiac injury by regulating fatty acid oxidation and ferroptosis.

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis

This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Global proteomics indicates subcellular-specific anti-ferroptotic responses to ionizing radiation

The paper uses global subcellular proteomics to identify subcellular-specific anti-ferroptotic responses in A549 cells exposed to ionizing radiation, highlighting potential mechanisms of radio-resistance.

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

Mitochondrial genome-encoded mitomiRs regulate cellular plasticity and susceptibility to ferroptosis in triple-negative breast cancer

This study identifies mitochondrial-encoded miRNAs (mitomiRs) that regulate ferroptosis sensitivity in triple-negative breast cancer by modulating ZEB1 expression and metabolic reprogramming.

PRDX6 dictates ferroptosis sensitivity by directing cellular selenium mobilization

The paper shows PRDX6 influences ferroptosis sensitivity by managing cellular selenium levels, which affects GPX4 function.

Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

The paper identifies SLC7A11-mediated cysteine metabolism as a target to overcome trastuzumab resistance in HER2 positive breast cancer by inducing ferroptosis.

NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

This study shows that NOLC1 suppresses cisplatin chemotherapy and immune checkpoint inhibitor therapy in gastric cancer by inhibiting p53-mediated ferroptosis.

ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells

This study identifies ACSS2's role in regulating ferroptosis in breast cancer brain metastatic cells through E2F1-dependent mechanisms, showing ACSS2 inhibition reduces metastatic growth.

Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis

This study shows that DDI2 activates NFE2L1 to protect cells from ferroptosis by regulating the ubiquitin-proteasome system.