Animal Virus Infections Studies

A divergent betacoronavirus with a functional furin cleavage site in South American bats

The paper reports a new bat betacoronavirus from Brazil with a functional furin cleavage site in its spike protein, highlighting its phylogenetic distinctiveness and potential zoonotic risk.

Porcine epidemic diarrhea virus infection promotes Peyer's patch immune induction and epithelial defense via single-cell transcriptional reprogramming

This study uses scRNA-seq to analyze how PEDV infection alters transcriptional responses in intestinal epithelial and immune cells, identifying a conserved antiviral gene signature in enterocytes.

Conserved structural features of RNA export pores spanning the double membrane of arterivirus and coronavirus replication organelles

The paper models the arterivirus nsp2 and nsp3 proteins to identify conserved structural features of DMV pores, revealing their role in RNA export and viral replication.

Identification of novel hepaciviruses in rock pigeon (Columba livia )

This study identifies three new hepaciviruses in birds, revealing phylogenetic incongruence and suggesting past cross-species transmission among avian hepaciviruses.

Discovery of a cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions

The paper identifies a [4Fe-4S] cluster in PRRSV Nsp1α leader protease, showing its role in modulating protease activity and host-virus interactions.

A novel genetically distinct Amdoparvovirus in Sorex araneus in the United Kingdom highlights an unexplored ancestral link

The study identifies a novel amdoparvovirus in shrews, challenging the notion that these viruses are restricted to carnivores and highlighting the need for broader wildlife surveillance.

The dynamics and strategy of RNA replication in astroviruses

This study investigates RNA replication dynamics in astroviruses using high-throughput sequencing, revealing a conserved premature termination model for subgenomic RNA production.

First Detection of Recombinant Enterovirus G Carrying a Torovirus Papain-like cysteine protease Gene from India

The study reports the first detection of a type I recombinant EV-G1 strain carrying a torovirus PLCP gene from India, showing genetic similarity to strains from South Korea, China, and Japan.

Picornaviridae and Caliciviridae diversity in Madagascar fruit bats is driven by cross-continental genetic exchange

The paper identifies and describes Picornaviridae and Caliciviridae viruses in Malagasy fruit bats, finding evidence of cross-continental genetic exchange shaping their diversification.

The C terminus of infectious bursal disease virus (IBDV) VP3 encodes a predicted intrinsically disordered region (IDR), which promotes the formation of cytoplasmic puncta and modulates their physical properties.

Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection

This paper creates a mouse-adapted SADS-CoV virus and a neonatal mouse model to study its infection and evaluate antiviral treatments.

Genome sequence and annotation of ovine herpesvirus-1

This paper reports the genome sequence and annotation of ovine herpesvirus-1, identifying conserved and unique genes among macaviruses.

Viral diversity, ecological interconnectedness, and the identification of mammalian chuviruses in Australian microbats

The paper identifies a new lineage of chuviruses in Australian microbats and reveals high viral diversity and connectivity among microbat species.

First full-genome alignment representative for the genus Pestivirus

The paper provides the first full-genome multiple sequence alignment for all known pestivirus species and identifies conserved and novel RNA secondary structures.

United States PRRSV 1-4-4 L1C.5 isolate demonstrates similar pathogenicity to a historic Chinese highly pathogenic PRRSV

This study compares the pathogenicity of PRRSV 1-4-4 L1C.5 to historical Chinese HP-PRRSV JXwn06 and US strain MN184 in weaned pigs, finding L1C.5 and JXwn06 cause more severe disease than MN184.

Comparative impact of porcine reproductive and respiratory virus and swine influenza A virus infections on respiratory lymph nodes B cells and macrophages.

This study compares the effects of PRRSV-1 and swine influenza A virus on respiratory lymph node B cells and macrophages, identifying PRRSV-specific immune evasion mechanisms.

Identification and characterization of a non-peptidic cyclophilin ligand with antiviral activity against feline and porcine α-coronaviruses.

This study identifies a non-peptidic cyclophilin ligand, F83233, that inhibits replication of feline and porcine alpha-coronaviruses in multiple species.

Dipeptidase 1 is a functional receptor for coronavirus PHEV

This study identifies dipeptidase 1 as the receptor for PHEV, showing it does not require sialic acid and reveals structural versatility in receptor binding.

Rodents as Potential Reservoirs for Toroviruses

The paper identifies a novel torovirus in a dormouse, suggesting rodents may be a reservoir for toroviruses and highlighting their potential for cross-species transmission.

High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions

The paper uses long-read sequencing to analyze intrapopulation diversity in tandem repeat regions of Mareks disease virus strains, revealing phenotypic links to virulence and attenuation.

Identification and characterization of novel bat coronaviruses in Spain

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor

This paper identifies a functional interleukin-4 homolog in the infectious laryngotracheitis virus genome, showing it enhances virulence and immune evasion.

229E- and NL63-like coronaviruses in phyllostomid bats, Belize

The paper identifies novel and previously known alphacoronaviruses in three bat species in Belize and finds phylogenetic similarity between bat CoVs and human 229E and NL63 coronaviruses.

Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and their Housemates

This study compares FCoV RNA levels in FIP cats and their housemates across blood, conjunctiva, and feces, finding no difference between groups but higher levels in feces overall.

Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment

This paper describes a case of re-emerging feline infectious peritonitis (FIP) in a cat with neurological signs, highlighting the use of GS-441524 and remdesivir treatment and the role of AGP monitoring in detecting relapse.

Infectious Bronchitis: Molecular Detection and Characterization in Live Bird Markets in Jos, Plateau State, Nigeria

This study detects and characterizes infectious bronchitis virus in live bird markets in Nigeria, identifying two genotypes with notable relationships to known strains.

The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes

This study compares innate immune responses in newborn and weaned piglets infected with two PEDV strains, finding that weaned piglets have stronger antiviral and pro-inflammatory responses despite similar viral replication.

Detection of Deltacoronavirus in Environmental Fecal Samples from Seabirds in the Saint Peter and Saint Paul Archipelago, central equatorial Atlantic Ocean

The paper detects deltacoronaviruses in environmental fecal samples from seabirds in the Saint Peter and Saint Paul Archipelago using RT-PCR and metatranscriptomics.

Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host

This study compares immune responses and pathogenesis in pigs infected with two porcine respiratory coronavirus strains, finding that a more severe strain induces stronger inflammation and immune responses linked to pneumonia.