Peripheral Neuropathies and Disorders

Autoantibodies from recovered Guillain-Barre syndrome patients exhibit altered effector functions that prevent subsequent neuron degeneration

This study shows that some GBS patients retain anti-ganglioside antibodies years after recovery, which no longer damage neurons but may still offer protection against C. jejuni.

Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barre syndrome

This study identifies transcriptomic signatures in GBS patients that reveal leukocyte interactions with peripheral nerves and pain pathways, suggesting therapeutic targets for neuropathic pain.

Multi-omic characterization of human sural nerves acrosspolyneuropathies

The paper integrates single nuclei transcriptomics and spatial transcriptomics of human peripheral nerves to identify novel cell markers, reveal pan-nerve disease characteristics, and demonstrate potential for unbiased diagnostic classification.

Expression of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Human Peripheral Nervous System: Implications for the Putative Pathogenic Role of FGFR3 Autoantibodies in Neuropathy

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.

This study identifies genetic risk loci and candidate genes for inflammatory polyneuropathy and CIDP through GWAS and functional analyses.

Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM-1 and CD1

The paper investigates the association between genetic polymorphisms in IL-17, ICAM-1, and CD1 genes and susceptibility to Guillain-Barré Syndrome (GBS) in a mestizo population during a 2018 outbreak.