Spaceflight effects on biology

Real-time, in situ fluorescence and optical density measurements of liquid cultures in simulated microgravity

This paper develops an in situ spectroscopy system for real-time measurement of microbial growth and metabolic activity in simulated microgravity.

ExocubeBio: an in-situ fluidic platform for microbial exposure on the International Space Station

ExocubeBio is a miniaturized platform for exposing microbes to space conditions, enabling in-situ measurements and sample return for analysis.

A coupled cerebro-ocular-CSF lumped-parameter model under gravitational and postural variations

The paper develops a coupled cerebro-ocular-CSF model to simulate pressure dynamics under gravitational changes, showing posture-dependent IOP increases and a pressure drop in the optic nerve subarachnoid space.

Cosmic silence and viral noise: transcriptomic crosstalk in Caenorhabditis elegans under simulated space conditions

This study examines how simulated space conditions affect viral infection in C. elegans, finding that abiotic stressors reduce viral replication and alter host gene expression.

Turning green in microgravity: facial color changes as best physiological indicator of space sickness

This study investigates physiological indicators of motion sickness, finding that increased skin greenness correlates with motion sickness severity in different sensory conflict scenarios.

Simulated Microgravity Recapitulates Aspects of Biological Aging in Humans

This study uses simulated microgravity to model biological aging in humans, finding similar transcriptional changes to natural aging across multiple systems and aging hallmarks.

MicroAge Mission: Experimental Design, Hardware Development and Operational Considerations for a Bespoke Culture System to Support Tissue-Engineered Skeletal Muscle Constructs.

The paper describes the design and operational considerations of a tissue-engineered skeletal muscle system for microgravity experiments to study muscle atrophy and aging mechanisms.

Microgravity affects the nervous system and aging in C. elegans through reduced tactile stimulation

This study shows microgravity reduces mechanoreceptor gene expression in C. elegans, causing neuromuscular defects and accelerated aging, but physical stimulation in space can reverse these effects.

Effects of Simulated Microgravity on Human Hematological and Anemia-Related Biomarkers: A Systematic Review and Meta-Analysis

This study reviews and analyzes the effects of simulated microgravity on hematological and anemia-related biomarkers in humans, finding hemoconcentration, erythropoietin suppression, and altered iron metabolism.

Effects of microgravity on the three-dimensional morphology of rhizoids in Physcomitrium patens

This study examines microgravity effects on rhizoid morphology in Physcomitrium patens using 3D micro-CT data and machine learning, finding suppressed elongation and gravitropic responses under microgravity.

Integrated Cross-Species Translation and Biophysical Multi-Scale Modeling Links Molecular Signatures and Locomotory Phenotypes in Spaceflight-Induced Sarcopenia

The paper identifies conserved molecular pathways in spaceflight-induced sarcopenia using cross-species analysis and develops a model linking transcriptional changes to locomotion deficits.

Validation of Gentamicin and Streptomycin Stability for On-Orbit Microbial Monitoring

This study validates the stability of gentamicin and streptomycin in agar plates over 6.5 months at 4°C, finding slight degradation but overall stability suitable for the GEARS project.

Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and miRNA Suppression

The paper analyzes PBMCs from astronauts before and during spaceflight to show microgravity induces telomere elongation, DNA repair activation, and miRNA suppression, suggesting a molecular longevity program in immune cells.

Dynamic alterations of DNA methylation and transcriptome in adaptation to and recovery from the space environment

The paper analyzes DNA methylation and transcriptome changes in astronauts during and after spaceflight, identifying epigenetic adaptations and recovery patterns.

Single-cell transcriptomics reveals spaceflight-induced accelerated aging and impaired recovery in the murine bone marrow

This study uses single-cell transcriptomics to show that spaceflight causes accelerated aging and impaired recovery in old mice's bone marrow, with specific dysregulation in erythroid and B cells.

Dormant viral pathways underlie space-induced neural senescence: a neuroprotective strategy for spaceflight and neurological diseases

The paper shows that spaceflight triggers neural senescence via reactivation of dormant viral-like retroelements, and that reverse transcriptase inhibitors can reverse these effects.

GLARE: Discovering Hidden Patterns in Spaceflight Transcriptome Using Representation Learning

GLARE applies representation learning to spaceflight transcriptomics, confirming existing findings and uncovering new gene expression patterns in Arabidopsis under spaceflight conditions.

Spatiotemporal Microbial Ecoevolutionary Dynamics on the International Space Station

This study analyzes the ISS microbiome over seven years, revealing stable core communities with localized microevolution and AMR/virulence dynamics that require functional validation.

Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice

This study examines how simulated lunar gravity and heavy ion radiation affect mitochondrial quality control in mouse skeletal muscle, finding radiation suppresses key transcriptional regulators while simulated gravity has no effect.

Gravity-Dependent Metabolomic Responses in Starbor Kale Brassica oleracea: Comparisons With Simulated Microgravity Versus Gravity Grown

This study compares metabolomic responses of kale grown in simulated microgravity and gravity conditions to understand gravity-related metabolic adaptations.

A Multi-lensed Comparative Analysis of Select Secondary Metabolites Produced by Kale, Brassica oleracea, in Simulated Microgravity Versus Gravity Conditions

This study examines how simulated microgravity affects the secondary metabolite profile of kale, finding increased flavonoid production under microgravity conditions.

Hypothetical LOC Genes as Biomarkers of Spaceflight Adaptation: A Comparative Study from ISS, Suborbital, and Earth-Based Experiments

This study identifies LOC genes with significant expression changes in astronauts during spaceflight, suggesting they may serve as biomarkers for microgravity adaptation.

AI-Based Comparative Transcriptomics and Gene Network Profiling of Staphylococcus aureus in Astronaut-Associated Missions

This study identifies conserved transcriptomic signatures and metabolic reprogramming in Staphylococcus aureus across spaceflight-associated conditions using comparative transcriptomics and gene network analysis.

Microgravity Accelerates Skeletal Muscle Degeneration: Functional and Transcriptomic Insights from a Muscle Lab-on-Chip Model Onboard the ISS.

This study uses a muscle lab-on-chip model on the ISS to show microgravity accelerates muscle degeneration, with younger muscles showing increased aging gene expression under microgravity when stimulated.

Prolonged exposure to hypergravity increases biomass and alters biomass allocation in Arabidopsis thaliana (L.) Heynh. with no apparent impact on element content in the shoot system

This study examines the effects of 10 g hypergravity on Arabidopsis thaliana biomass and element content, finding increased biomass but no changes in mineral element levels.

Integrative cardiovascular dose-response to graded lower body negative pressure

This study constructs dose-response curves for lower body negative pressure (LBNP) to quantify cardiovascular effects across different postures and identifies its potential to reduce jugular venous flow stagnation during spaceflight.

Flight-Scope: microscopy with microfluidics in microgravity

Flight-Scope enables live-cell imaging of dynamic processes in microgravity using microfluidics during parabolic flights, demonstrated with yeast glucose uptake.

Assessing Immune Stability in Space: Haematological and T Cell Profiling of Astronauts During the MESSAGE Science Mission in Axiom-3 on the ISS

This study examines haematological and T cell changes in astronauts during short-term spaceflight, finding stable parameters but suggesting further research is needed for long-term immune adaptations.

Protective Effects of Minocycline and Acetazolamide on Visual Function in Simulated Microgravity Rats

This study evaluates the protective effects of minocycline and acetazolamide on visual function in rats subjected to simulated microgravity, showing both drugs mitigate visual impairments through different mechanisms.

Multidirectional effect of low-intensity neuromuscular electrical stimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse

This study examines how low-intensity neuromuscular electrical stimulation affects gene expression and muscle phenotype during one week of disuse, showing mixed benefits depending on muscle type.