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This paper evaluates methods for modeling multi-state protein and RNA systems in CASP16, finding improved accuracy for some targets but persistent challenges in capturing structural details for others.

This study shows that membrane-tethering of honeybee defensin1 in Drosophila boosts antimicrobial efficacy but increases host vulnerability under stress.

This study uses chemoproteomics to show that calprotectin stress in Acinetobacter baumannii leads to undermetalation of metalloproteomes, impairing key metabolic and cellular processes.

This study uses stable isotope labelling to investigate N2O production in chicory roots and shoots under different light conditions, revealing distinct formation pathways in roots and shoots.

This study shows that PREPL deficiency causes mitochondrial dysfunction, leading to lipid accumulation and altered peroxisome morphology, but not direct lipid metabolism regulation.

The paper investigates the relationship between oxidative stress markers and atherosclerotic plaque progression in diabetic and hypertensive patients through clinical and animal studies.

The paper demonstrates a method to create extended plasmonic nanostructures using tobacco mosaic virus coat protein templates, forming hexagonal or square packed sheets and core-shell nanorods with gold nanoparticles.

FibrilPaint1 measures Tau amyloid fibril length in fluids using fluorescence and microfluidics, enabling diagnostic and research applications in neurodegenerative diseases.

The paper designs a modified tyrosinase enzyme with a substrate recruitment domain to selectively modify tyrosine residues in peptides, enabling efficient bioconjugation of cytotoxic molecules to antibodies.

The paper presents a thermodynamic model explaining super-additivity in similar drug combinations, with implications for cysteine-derived compounds and opioid withdrawal treatment.

This study identifies and quantifies site-specific collagen post-translational modifications (PTMs) in human adrenal extracellular matrix, revealing intra-tissue heterogeneity in PTM occupancy and potential functional implications.

This study investigates how the human mitochondrial processing peptidase (MPP) recognizes and processes the N-terminal targeting sequence of PINK1, revealing its binding mechanism and functional implications.

This study identifies key biosynthetic enzymes in methylenomycin production and discovers more potent intermediates active against drug-resistant Gram-positive bacteria.

This study identifies molecular determinants of weak PDZ1/Cx36 interactions, showing that specific residues and phosphorylation regulate electrical synapse stability.

This study identifies calcium as a key regulator of Annexin-A11's function in RNA transport and its disruption in ALS by revealing its conformational switch and domain interactions.

The paper identifies a potent BRD9 degrader, AMPTX-1, which selectively recruits BRD9 to DCAF16, leading to its degradation in vivo.

The paper introduces a method to impute missing proteomics data using regularized regression and biological covariation, achieving high accuracy across multiple measurement modalities.

The paper reports the cryo-EM structure of the GRP170-ATP-BiP complex, revealing a new model for substrate engagement and GRP170's pseudo-ATPase activity.

This study identifies cA5 as the activator for ApCsm6, a type III CRISPR ribonuclease, and reveals its structural basis for cA5-selective recognition and self-limiting activity through Cryo-EM structures.

This study shows that silk fibroin inhibits α-synuclein amyloid aggregation through structural and kinetic modifications, increasing susceptibility to enzymatic degradation.