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This paper reports a unique crystal structure of the c-Src SH3 domain mediated by nickel ions, revealing a 2:2 stoichiometry and dimerization mechanism.

This study shows that APE1's Asn174 residue stabilizes the AP-site through hydrogen bonding and electrostatic interactions, which are essential for catalytic activity.

The paper develops an in silico-in vitro workflow to generate high-affinity antibodies targeting the KRAS(G12D)-MHC I complex, achieving nanomolar affinity and specific T cell activation.

This paper applies statistical causal discovery to ecotoxicology data to improve adverse outcome pathway models by identifying causal relationships and handling missing data.

HyperLab accelerates drug discovery by providing an AI-driven platform with tools for ligand-protein binding prediction, molecular optimization, and compound screening, achieving high accuracy and speed in benchmark tests.

This paper uses a generative AI model to design novel tryptophan synthase variants with enhanced catalytic activity and substrate promiscuity, outperforming natural and optimized versions.

GlycoEnzDB curates and presents human glycoenzyme data, linking enzyme functions, pathways, and expression data with external resources and AI-generated descriptions.

The paper identifies a conserved salt bridge between KIF1A R350 and -tubulin E415, whose disruption in pathogenic variants correlates with altered motor function.

This study investigates how α-synuclein fibril morphology changes during formation, storage, and exposure to ligands, showing continuous structural evolution and ligand-induced morphological shifts.

This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.

The paper characterizes ChlH, a flavin-dependent halogenase that halogenates internal and terminal tryptophan residues in diverse peptides and proteins, showing broad substrate promiscuity.

This study identifies SAM hydrolases in thermophilic archaea that counteract sulfonium epimerisation, maintaining metabolic stability by degrading inactive (RS,SC)-SAM.

This study evaluates linker types for enhancing crystallization of proteins fused to TELSAM, finding that linker choice depends on the target protein's properties.

This study determines the structural basis of Fusobacterium nucleatum adhesin Fap2 interactions with Gal-GalNAc and TIGIT, revealing binding mechanisms and structural details.

The paper identifies Tue1, a fungal effector from Thecaphora thlaspeos, which interacts with JAZ10 to modulate jasmonate signaling in plants, suggesting a conserved structural effector family in fungal pathogens.

This study reports cryo-EM structures of ArsA, an ATPase involved in arsenite efflux, showing conformational changes driven by nucleotides and AsIII binding.

The paper analyzes sterol diversity in pollen from 295 UK wildflower taxa and finds that sterol composition is conserved within plant lineages and important for bee nutrition.

The paper assesses the overbinding of monovalent cations to phosphorylations in forcefields, identifies it as an artifact, and proposes a parameterization strategy to improve accuracy.

This study identifies the structural basis of VCP-VCPIP1-p47 complex formation and demonstrates the role of VCPID in enhancing DUB activity and Golgi reassembly.

This study shows that the catalytic pocket of Clr4 (Suv39h) acts as a receptor for Cul4-dependent H3K14 ubiquitination, which regulates Clr4's methylation activity on H3K9.