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Q-MOL improves drug discovery by accurately predicting ligand binding sites on flexible and disordered proteins, validated across diverse targets and experimental settings.

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

This study synthesizes oligosaccharides from Streptococcus pneumoniae serotypes 35B and 35D to investigate their binding to complement and serum factors, revealing the role of O-acetylation in immune evasion and vaccine efficacy.

The paper identifies TcIMPDH as a druggable target for Chagas disease and shows AVN-944 has potent inhibition and selectivity in infected cells.

This paper develops a hemoprotein-based CO scavenger that selectively removes CO from hemoglobin, accelerates its clearance, and avoids hypertension compared to hemoglobin-based treatments.

The paper presents the cryo-EM structure of the LRRK2:14-3-32 complex, showing how 14-3-3 binding inhibits LRRK2 activity and how PD mutations disrupt this interaction.

The paper identifies a conserved 10-transmembrane helical fold in diverse acyl transferases, defining the TmAT superfamily involved in transmembrane acyl-group transfer.

This paper introduces a quantitative MSI workflow using 13C-labeled yeast extract to enable reliable spatial metabolomics, revealing metabolic changes in the ipsilateral cortex after stroke.

This study identifies Cor a 8, a non-specific lipid-transfer protein, as a novel lipase in hazelnuts that hydrolyzes triglycerides and contributes to lipid oxidation.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

This study compares antioxidant enzyme activity and lipid peroxidation levels between type 2 diabetes patients with good and poor glycemic control and healthy controls in Cameroon.

This study characterizes bacterial FKP enzymes, revealing evolutionary origins and functional diversity through biochemical and phylogenetic analyses.

The paper presents cryo-EM structures of the rice Pi transporter OsPHT1;11 and reveals its conformational dynamics and mechanism for phosphate uptake.

This study measures cardiac metabolite exchange in pigs during myocardial ischemia and reperfusion, revealing dynamic metabolic changes and transient protein degradation.

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

The paper purifies amylase from Bacillus subtilis A4 using ammonium sulphate precipitation, ion-exchange chromatography, and gel filtration, achieving a 49% yield after six purification steps.

The paper determines the sub-nanometer structure of the SUN5-Nesprin3 LINC complex in human sperm cells, revealing its role in nuclear envelope remodelling and male infertility.

The paper uses structural and biochemical analysis to show that ATPase-driven translocation of σN-RI through a DNA bubble activates transcription initiation by disrupting inhibitory structures.

This paper develops a protein-based delivery system for anti-CRISPR proteins to precisely control Cas9 activity, reducing off-target effects and improving genome editing specificity.

This paper identifies covalent modulators that target and degrade IRF5 and IRF8, key inflammatory transcription factors, with TH-B10 showing potent and selective degradation of IRF8.