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High-Field Multinuclear MRI Reveals Sodium Relaxation Heterogeneity in Cortical Organoids

This study uses high-field multinuclear MRI to analyze sodium relaxation heterogeneity in cortical organoids, revealing distinct relaxation components and spatial microenvironment variations.

Fluid forces control structural remodeling of blind-ended lymphatic microvessels

This study shows how fluid forces and VEGF-C drive lymphangiogenesis and structural remodeling of blind-ended lymphatic vessels using a microphysiological system.

The Sniffbot: A biohybrid robot for active sensing-based odor localization and discrimination

The paper introduces Sniffbot, a biohybrid robot that uses a locust antenna to detect and localize odors more effectively than existing methods.

Cell Barcoding Reveals Lineage-dependent Outcomes in hiPSC Cardiac Differentiation

The paper uses cell barcoding to show that hiPSC lineages have different differentiation outcomes into cardiomyocytes, highlighting lineage-dependent variability in cardiac differentiation.

miRNova: A Next-Generation Platform for Ultra-Precise and Highly Specific MicroRNA Quantification Integrating a Tailored Stem Loop RT-qPCR and a Robust Analytical Framework

The paper introduces miRNova, a platform for precise miRNA quantification using tailored stem-loop RT-qPCR and an analytical framework, showing superior specificity and accuracy in saliva samples.

Metabolic engineering of Corynebacterium glutamicum for production of the low-caloric natural sweetener D-allulose via phosphorylated intermediates

This paper engineers Corynebacterium glutamicum to produce D-allulose via a phosphorylation-dephosphorylation pathway, achieving a 2.3-fold increase in production in minimal medium.

Carbon Capture Modeling and Simulation Platform: A Coupled Microalgal Bioreactor-Yeast Fermentation Approach for Bioethanol

The paper develops a simulation platform for carbon capture using microalgae and yeast to convert CO2 to bioethanol, showing process efficiencies up to 93.78% of theoretical maximum.

Modeling a Shared Reality of Tractography through Varied Structural Imaging

This paper introduces a method to generate white matter tractograms from FLAIR images without diffusion data, showing it captures structural probabilities similar to diffusion-based tractography.

Left atrial flow and thrombosis risk from 4D CT contrast dynamics by physics-informed neural network and indicator dilution theory

This paper develops two methods to estimate left atrial blood residence time from 4D CT contrast data, showing that indicator dilution theory provides faster, more accurate results than a physics-informed neural network.

Can predictive simulations of walker-assisted gait using calibrated muscle models capture subject-specific walking features in individuals with spinal cord injury?

This paper evaluates if predictive simulations with calibrated muscle models can replicate subject-specific gait features in spinal cord injury patients, finding partial success with functional calibration methods.

Inertial sensing of water content in tumor spheroids

This paper measures water content in tumor spheroids using a steel tube resonator, achieving <1% precision error and detecting inter-spheroid variability and responses to kinase inhibition.

StrataChip: a microphysiological system capturing dynamic keratinocyte fate and mechanical transitions during human epidermal morphogenesis

StrataChip enables dynamic study of human epidermal morphogenesis by integrating microfluidics with single-cell RNA-sequencing and imaging, revealing transcriptional and mechanical transitions during stratification.

IL12-engineered human PSMA-CAR T cells for the treatment of advanced prostate cancer

This study develops and tests IL12-engineered human PSMA-CAR T cells for advanced prostate cancer, showing improved anti-tumor activity and safety.

Reconstituting organotypic 2D microtissue co-cultures via sequential stenciling

This paper introduces a stencil-based method to create 2D microtissue co-cultures with spatial precision, demonstrating applications in tumor microenvironment modeling, morphogen gradient studies, and intestinal architecture recreation.

In silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locations

This study assesses arrhythmic risk from engineered heart tissue implantation in porcine hearts with different infarct locations using computational models.

Early Prediction of Ischaemic Stroke Outcomes: A Novel Computational Approach

This paper introduces a computational pipeline to predict brain swelling after stroke using a mathematical model and deep neural network, achieving an AUC of 0.7 in predicting 3-month outcomes.

Systemic Delivery of Human Mesangioblasts mediated by a Nanofiber Scaffold restores Dystrophin Expression in Immunodeficient Dystrophic Mice.

This paper describes a method using a nanofiber scaffold to deliver mesangioblasts systemically, restoring dystrophin expression in DMD mice.

Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts

The paper evaluates the variability of GAMLSS-based brain charts using analytic and empirical methods, finding low coefficient of variation across most white matter features.

Digital Twins for Fungal Computing: Viable XOR Regimes, Parameter Inference, and Waveform-Guided Rediscovery

This paper develops a digital-twin framework for fungal excitable networks to identify viable XOR computation regimes and refine biophysical parameters using waveform matching.

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.