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Towards Translational Sleep Staging: A Cross-Species Deep-Learning Model for Rodent and Human EEG

This paper develops a cross-species deep learning model for sleep staging in humans and rodents, achieving high accuracy without retraining.

An injectable soft implant for long-acting, reversible, ultra-stable release of therapeutics

This paper develops an injectable hydrogel platform with poly(orthoester) microparticles for long-term, zero-order drug release, demonstrating in vitro and in vivo efficacy for up to 12 months.

Microfluidic Mechanical Reactivation of Aged Stem Cells

This paper introduces a microfluidic platform to reactivate aged stem cells through mechanical stimulation, showing reduced oxidative stress and restored stemness markers.

Thermal Nano-Engineering of Ginger Extracellular Vesicles for Targeted Oral Therapy of Colitis

This paper describes a thermal processing method to enhance ginger-derived extracellular vesicles for targeted oral therapy of colitis, showing improved tissue accumulation and therapeutic efficacy.

Chronological Aging Stiffens Cells, Alters Mitochondria, and Impairs Mitochondrial Mechanical Responsiveness in Mesenchymal Stem Cells

This study shows that aging impairs mesenchymal stem cells by reducing osteogenesis, increasing adipogenesis, and decreasing mitochondrial mechanical responsiveness.

Volumetric mechanosensing of CAF in 3D hydrogels drive altered drug response in breast cancer

This study shows that 3D matrix stiffness affects CAF morphology and drug response in breast cancer by altering mechanotransduction and transcriptional programs.

Long-term moisture barrier performance of liquid crystal polymer for implantable medical electronics

This study evaluates the long-term moisture barrier performance of liquid crystal polymer (LCP) for implantable medical electronics through in vitro accelerated aging tests.

Scalable flow synthesis of ultrasmall inorganic nanoparticles for biomedical applications via a confined impinging jet mixer

This paper develops a scalable method to produce ultrasmall inorganic nanoparticles for biomedical use using a confined impinging jet mixer.

Highly sensitive enzyme- and amplification-free, quantitative DNA detection using YVO4:Eu luminescent nanoparticle probes

This paper develops a sensitive, amplification-free DNA detection method using YVO4:Eu nanoparticles, achieving 50 aM sensitivity for SARS-CoV-2 n1 gene detection.

Residual ellipticity in waveplate-compensated polarization-resolved SHG microscopy may arise from femtosecond laser spectral bandwidth

This study investigates residual polarization ellipticity in waveplate-compensated polarization-resolved SHG microscopy and identifies femtosecond laser spectral bandwidth as a potential cause.

Effect of Lead Body and Helix Design Variables on Implantation Success, Insertion Depth, and Muscle Torque in Left Bundle Branch Area: Insights from An Ex-Vivo Porcine Model

This study evaluates how helix design and axial force affect insertion success and muscle torque in porcine septum pacing leads.

Importance of tribo-pairs to mimic blinking in vitro for dry eye disease research

This study evaluates tribo-pairs for simulating blinking in dry eye disease research, finding that porcine eyelid-eyeball pairs better mimic physiological friction than glass alternatives.

Title: Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model

The paper uses optogenetic WNT activation in human gastruloids to study germ layer self-organization and finds it drives mesendoderm differentiation and patterning.

Surface Functionalized RBC Membrane-Derived Nanoparticles for Targeted Drug Delivery to Attenuate Fatty Liver Disease

This study develops hepatocyte-targeting cell membrane-derived nanoparticles loaded with resmetirom to treat MASLD, showing improved bioactivity in vitro.

A novel endosome-escaping, macrophage-targeted nanoparticle platform for miR-146a delivery with favorable in vivo biodistribution and biocompatibility

Integrating Virtual Pivot Point and Trunk Dynamics to Understand Human Walking on Slopes: Insights from Experiments and Modeling

This study investigates how the Virtual Pivot Point (VPP) strategy and trunk dynamics adapt during slope walking through experiments and simulations, showing their role in stability and energy management.

Model predictive game control for personalized and targeted interactive assistance

This paper develops a model-predictive game controller for contact robots to improve human-robot interaction by predicting human control and adapting to individual motor strategies.

Rational Design Reveals Structural Plasticity of the CsgA β-Solenoid Enabling Programmable Autogenic Engineered Living Materials

The paper designs CsgA variants with altered β-strand lengths to explore structural plasticity in microbial β-solenoids, revealing how strand length affects nanofiber stability and material properties.

Flexible thin-film Implant with Depth Selectivity for Intraspinal Microstimulation

This paper introduces flex-ISMS, a flexible thin-film implant for intraspinal microstimulation, demonstrating depth selectivity and functional motor unit recruitment in pigs.

Regulatory network and spatial modeling reveal cooperative mechanisms of resistance and immune escape in ER+ breast cancer

This study models regulatory networks and spatial dynamics in ER+ breast cancer to show how resistance and immune escape co-occur and how combination therapies can counteract these mechanisms.