Discover, rate, and verify biology preprints.

Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D Hydrogels

This study shows that vascular network formation by hiPSC-derived endothelial progenitors in 3D hydrogels depends on matrix stiffness, contractility, and cell-induced remodeling, not just mechanotransduction.

Charge-screening dominates signal transduction in electrochemical nucleic acid sensors for aminoglycosides

The paper shows that charge-screening, not structure switching, is the main signal transduction mechanism in aminoglycoside electrochemical aptamer sensors.

Self-supervised Internal Learning Enhances Isotropic Resolution for Three-dimensional Fluorescence Microscopy

This paper introduces DeepIso, a self-supervised framework that enhances isotropic resolution in 3D fluorescence microscopy by restoring axial frequency content without requiring explicit PSF models or system calibration.

Impacts of Morphology and Elasticity on Cancer Cell Deformation in Shear-flows

This paper examines how cancer cell morphology and elasticity affect deformation under shear-flow, showing morphology sets stiffness-modulated deformation patterns that influence extracellular flow dynamics and traction.

Ultrasound-activated drug release with extracellular vesicles

This paper develops ultrasound-responsive extracellular vesicles for targeted drug delivery to the nervous system, demonstrating controlled release and pain modulation in rats.

A nonlinear time-domain finite-element model of the human middle ear subjected to intense sound waves

This study develops a nonlinear finite-element model of the human middle ear to simulate its response to intense sound waves and identifies nonlinear behaviors under high-frequency and high-intensity conditions.

Bacterial Swarming-Guided Biomineralization Enables Pattern Formation in Engineered Living Materials

This study shows how bacterial swarming guides calcium phosphate mineralization to form concentric patterns in engineered living materials.

Knee Joint Biomechanics During Lunges at Different Tibial Angles and External Loads: A Musculoskeletal Analysis with Finite Element Insights

This study examines knee joint biomechanics during lunges with different tibial angles and external loads, finding increased joint moments at 60° tibial angle and reduced stiffness under external load.

Extrusion-Printed Silicone Microarchitectures for Geometry-Controlled Flow in Lateral Flow Diagnostics and Paper Microfluidics

This paper develops a silicone ink for high-resolution hydrophobic barriers on paper, improving fluid control and diagnostic sensitivity in paper-based diagnostics.

homeRNA Just Dropped! Streamlining Remote Blood Collection and RNA Stabilization for Smaller Sample Volumes with homeRNAdrop

homeRNAdrop simplifies remote blood collection and RNA stabilization for small samples, with successful pilot testing showing adequate RNA quality and yield.

GapDream: Active Synthetic Evidence Acquisition for Long-Tailed Medical Imaging

GAP DREAM improves medical image generation by actively acquiring synthetic evidence that reduces evidence gaps, achieving better performance with fewer samples than random or balanced methods.

NIR-II squeezed light-field microscopy enables high-speed volumetric imaging of deep-tissue dynamics in vivo

This paper introduces NIR-II squeezed light-field microscopy to enable high-speed volumetric imaging of deep-tissue dynamics in vivo, achieving 600 volumes per second with high resolution.

Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays

This paper introduces NSSL to enable scalable, uniform plasmonic biosensing for digital single-sEV analysis and molecular profiling in liquid biopsies.

StaBLE: digital metrics capture balance performance across a wide spectrum of balance tasks and abilities

The paper introduces StaBLE, a digital balance assessment tool validated against clinical scales, showing strong correlations and improved detection of fall risk.

A Computational Pipeline for Retinal Capillary Blood Flow Measurement using Adaptive Optics Line Confocal Ophthalmoscopy

This paper presents a computational pipeline for measuring retinal capillary blood flow using adaptive optics line confocal ophthalmoscopy, achieving accurate velocity measurements and improved motion correction.

hMSCs for Osteocyte-like Cell Networks within Strain-Stiffening Bottlebrush Polymer Hydrogels

This study shows that strain-stiffening bottlebrush polymer hydrogels promote osteocyte-like differentiation and functional connectivity in hMSCs compared to collagen matrices.

From Discovery Proteomics to Process-Informed Monitoring in Biomanufacturing Chassis Development

The paper evaluates proteomics platforms for metabolic pathway analysis in biomanufacturing chassis organisms, showing varying proteome coverage across different instruments.

Microgels enable iPSCs to assemble, expand, and differentiate into organoids -- from sizable to high throughput

This paper introduces a method using PEG microgels to enable reproducible, scalable iPSC organoid production and differentiation into specific tissues.

Functional Assessment of Cardiac Beat Dynamics Under Dynamic Flow: Insights from the Mera Microphysiological System

The paper introduces Mera, a microphysiological system for studying cardiac beat dynamics under dynamic flow, showing it can modulate beat rates with pharmacological agents and replicate physiological responses.

PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery

PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.