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3D neuroblastoma models expose divergent responses to magnetic hyperthermia and photothermal therapy

This study compares photothermal therapy and magnetic hyperthermia in 3D neuroblastoma models, finding that magnetic hyperthermia provides more uniform heating and proliferation control, while photothermal therapy shows variable effects and can paradoxically increase proliferation.

Estimating Body Segment Properties for Adults AcrossDiverse Body Morphologies: A Data-Driven GeometricFramework

This paper develops a data-driven framework to estimate body segment inertial properties across diverse adult body morphologies, outperforming existing methods, especially for higher BMI values.

Developing Anti-EGFR/Anti-HER2 Bifunctional Antibody for Solid Tumors by Protein Engineering

This paper develops a bispecific anti-EGFR/HER2 antibody to enhance antitumor effects by targeting both receptors and improving immune responses.

4D force patterning enables spatial control of angiogenesis

This paper demonstrates that 4D force patterning using a magnetically actuated vessel-on-a-chip platform enables precise spatiotemporal control over angiogenesis by modulating mechanical strain magnitude, frequency, and direction.

Full-Field Analysis Indicates Late Reperfusion Therapy Broadens and Mechanically Smooths the Borderzone During Post-Infarction Inflammation

This study shows late reperfusion therapy increases the infarct borderzone size and reduces stiffness gradients in post-MI rat hearts, potentially improving mechanical stability.

Combined computational and experimental analysis confirm donor-dependent optimization of critical processing parameters for improving mesenchymal stromal cell potency and expansion attributes

Intramuscular Delivery of BMP-2 and Increasing Doses of LECT-1 Using Keratin-PEG Gels for Ectopic Tissue Differentiation

This study uses keratin-PEG hydrogels to deliver BMP-2 and LECT-1 intramuscularly, showing that co-delivery enhances ectopic bone and cartilage formation in mice.

Residual Hair Biomaterial Particulates Improve Dermal Regeneration and Combined with Electrical Stimulation Accelerates Skin Wound Closure

This study evaluates the effects of residual hair biomaterial particulates, electrical stimulation, and their combination on skin wound healing, finding they accelerate closure and improve tissue regeneration.

Optical Spectral Fingerprinting Enables Sensitive Detection of Anthracycline Chemotherapeutics in Synthetic Clinical Biofluids

This paper develops an optical nanosensor array to detect anthracycline chemotherapeutics in synthetic biofluids using machine learning for classification and concentration analysis.

Tunable Rigid Spikes on Virus-Like Porous Silica Enable Mechanistically Controlled Nanovaccine Platforms

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

Colorectum and Embedded Networks of Nerve Fibers Present Auxetic Responses During Uniaxial Circumferential Extension

This study shows that colorectal tissue and its nerve fibers exhibit auxetic behavior during circumferential stretching, with measurable deformation at both macro and micro scales.

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function

This study uses music-inspired acoustic-piezoelectric stimulation to enhance macrophage extracellular vesicle production and control their therapeutic function by tuning polarization states.

Fucoidan-Coated Layer-by-layer Lipid Nanoparticles for the Generation of CAR-Macrophages

This study develops fucoidan-coated lipid nanoparticles (Fuc-LNPs) for improved RNA delivery to macrophages, demonstrating enhanced targeting and transfection efficiency compared to PEGylated controls.

Time-of-flight-resolved interferometric speckle-contrast optical spectroscopy (TOF-iSCOS) for depth-resolved blood-flow sensing

This paper introduces TOF-iSCOS, a method combining interferometric speckle-contrast optical spectroscopy with time-of-flight gating to enable depth-resolved blood-flow sensing, showing improved noise resistance and depth sensitivity.

Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes

This study shows that tunable hydrogels can enhance zone-specific chondrocyte phenotypes and promote zonally organized cartilage formation.

L-5--glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine Metabolism

This study uses [11C]glutamine PET to analyze glutamine metabolism in breast cancer mouse models, revealing subtype-specific metabolic differences and the impact of GLS1 inhibition.

Effects of Tempo, Dynamics, and String on Physical Exposure in Professional Violinists

This study investigates how tempo, dynamics, and string affect physical exposure in violinists, identifying variance patterns and supporting targeted prevention strategies.

Matrix stiffness induces endothelial network senescence

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

Machine Learning Guided Optimization of an Oral Microemulsion System: A Bayesian Optimization Approach

This study uses Bayesian optimization to design stable oral microemulsions, identifying high-performing formulations with improved drug loading and stability.

A-eye: Automated 3D MRI Segmentation and Morphometric Feature Extraction for Eye and Orbit Atlas Construction

This study introduces an automated 3D MRI segmentation method for the human eye and orbit, providing large-scale unbiased atlases for clinical research.