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This study shows that reprogramming CD4 T cells can eliminate HIV DNA reservoirs, offering a potential functional cure by restoring intracellular antiviral immunity.

This paper demonstrates that ALTA(R) vaccine particles provide sustained antigen release, improving immune response to single-shot vaccination compared to liquid regimens.

This study shows Salmonella SPI2 evades NAIP/NLRC4 detection by limiting SsaG expression, despite SsaG being detectable when artificially delivered.

The paper identifies putative antigen targets of a stereotyped intrathecal B cell response in multiple sclerosis by generating monoclonal antibodies and using IPMS/MS to screen against proteins.

This paper designs a rigid divalent immunogen that selectively binds VRC01-class antibodies with higher avidity than non-target antibodies, supporting its use in vaccine development.

The paper shows that sub-neutralizing concentrations of ZIKV IgM monoclonal antibodies reduce IgG-mediated antibody-dependent enhancement of infectivity in vitro and in infected individuals.

This study shows that post-COVID-19 mitochondrial dysfunction impairs T cell memory responses to pathogens, but can be improved with metformin and ubiquinol.

The paper identifies and classifies rare peripheral CD4+CD8+ double-positive T cells using single-cell RNA sequencing and machine learning, revealing their antigen-experienced features and cytotoxic potential.

This paper introduces CAR-T-drug conjugates (CAR-T-D-C) to improve CAR-T therapy for solid tumors by combining chemotherapy with CAR-T cells, enhancing tumor infiltration and immune response.

This study shows that switching CD8 with CD4 co-receptor in cytotoxic T cells reduces off-target cross-reactivity without altering the TCR, enhancing T cell therapy safety.

The paper develops a mathematical model to study how immune responses and metabolic pathway adaptations interact during infection, finding that glucose redistribution and cytokine regulation are critical for effective pathogen clearance.

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

This study compares memory B cell responses to mRNA and nanoparticle vaccines in mice, finding similar antibody sequences but better breadth from mosaic nanoparticle vaccines.

This study shows that blocking IL-4/IL-13 signaling can reprogram allergen-specific memory B cells from a pathogenic IgE fate to a non-pathogenic IgG2c fate.

The paper identifies regulatory compression as an organizational principle in hematopoiesis, showing how chromatin geometry influences information flow through selective pathways in progenitor and differentiated cells.

This study identifies fatty acids as regulators of stem-like exhausted CD8 T cells during chronic viral infection, showing their impact on mitochondrial fitness and viral control.

This paper introduces Pox-AbDab, a database of antibodies against orthopoxviruses, highlighting challenges in cross-species antibody function and identifying gaps in research.

The paper uses spatial molecular imaging data to map human tonsil architecture and provides an analytical framework for Spatial Immunology.

This study shows that short fixation times improve macrophage detection in immunofluorescent analysis of mouse and human tissues, without affecting other markers.