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This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

The paper analyzes 6 million T cells from 91 studies to identify TCR sequence convergence patterns and their association with functional and cellular T cell phenotypes.

This paper demonstrates the use of neoepitope-specific monoclonal antibody cocktails to treat B16F10 melanoma by targeting unique tumor mutations, showing in vitro and in vivo efficacy.

This paper develops a human microphysiological system to study neutrophil reverse migration mediated by macrophage-derived extracellular vesicles in sterile injury.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

This study identifies and characterizes the anatomical distribution of human lung macrophage subpopulations using single-cell RNA sequencing and finds smoking-induced changes in their accumulation patterns.

This study shows Giardia increases macrophage IL-10 production in response to LPS via MGL1, suggesting a mechanism for its anti-inflammatory effects.

This paper shows that the actin cytoskeleton regulates NADPH oxidase activation and G protein recruitment in neutrophils via Gq-coupled receptors.

This study identifies VGLL3 as a key driver of preeclampsia by linking it to placental, vascular, and immune defects, showing its therapeutic potential through genetic and pharmacological inhibition.

This study develops an in vitro method to enrich HLA-DQ-specific CD4 T cells using HLA-DQ monomers, enhancing detection of donor-specific T cells in naive individuals.

The paper shows that T cells entering the eye develop either suppressive regulatory or anergic phenotypes, with both arising from a common precursor, revealing a key checkpoint in ocular immune privilege.

This study shows Saccharibacteria suppress epithelial immune activation by clustering TLR2 via Type IV pili and endocytosis, reducing cytokine signaling and enabling long-term persistence in the oral microbiome.

This study evaluates monoclonal antibody responses to XBB.1.5 vaccines by analyzing plasmablasts from vaccinated individuals and characterizing their binding and neutralization properties against SARS-CoV-2 variants.

This study links increased transposable element (TE) expression in SLE patients to IFN responses, showing strong correlations with disease activity and splicing alterations.

This study investigates the role of CCL4 and its receptor CCR5 in MAYV infection and finds no significant effect on disease progression or immune response.

The paper compares RNA distribution in polysomes between male and female neutrophils, finding sex-based differences in translation efficiency and mRNA enrichment.

This study shows that mucosal BCG vaccination induces lung CD8+ TRM cells via TGF-β activation by airway epithelial progenitors, linking tissue repair to immune memory.

The paper reanalyzes mass spectrometry data to identify two new compound classes that bind to MR1, using fragmentation filtering, molecular networking, and spectral database searching.