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Single-nucleus multiome profiling reveals osteocyte-centered remodeling of human subchondral bone across osteoarthritis severity

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

Arthroscopic Raman Probe Provides Biomarkers of TMJ Tissue Composition that Account for Tissue Function

This study validates arthroscopic Raman spectroscopy for quantifying TMJ tissue composition and mechanical properties, showing strong correlations with indentation and tensile modulus.

Ex vivo autologous immune cell assay to study modulation of type 2 Inflammation by processed- or novel food extracts in peanut allergy

This paper introduces an ex vivo assay to study how peanut extracts and novel foods modulate type 2 inflammation in peanut-allergic patients.

Salience network expansion as a transdiagnostic neural marker for psychopathology risk in adolescence

The paper examines whether increased salience network surface area in adolescents is specific to depression or a general marker of psychopathology, finding stronger associations with overall psychopathology than depression alone.

Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy

This study identifies FASN as a regulator of mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy, linking lipid metabolism to epigenetic changes and cardiac disease.

Digital twins forecast individual immune trajectories

The paper introduces ImmuneTwins, a digital twin framework that personalizes immune response models for individuals, improving prediction accuracy of immune trajectory changes.

PD-L1 deletion or blockade regulate macrophage antigen presentation and checkpoint molecule surface levels

This study investigates how PD-L1 deletion or blockade affects macrophage antigen presentation and checkpoint molecule levels in different polarization states.

Multivariate Mutual Information based Feature Selection for Predicting Histone Post-Translational Modifications in Epigenetic Datasets

This paper introduces multivariate mutual information (MMI) for selecting histone PTM features to predict epigenetic data, showing improved accuracy over traditional methods.

Assessing Zymoseptoria tritici Candidate Effectors in the Non-Host Nicotiana benthamiana Reveals Immune Recognition and Potential Host-Independent Activities

The paper assesses Zymoseptoria tritici candidate effectors in Nicotiana benthamiana to identify immune recognition and potential host-independent activities, finding that expression timing and signal peptides influence effector phenotypes.

Alterations in phototransduction timing, dark adaptation and GNAT1 trafficking in GNAT1-edited Xenopus laevis.

The paper examines the effects of GNAT1 mutations in Xenopus laevis, showing altered phototransduction timing, dark adaptation, and GNAT1 trafficking in different genetic backgrounds.

Genomic insights into the human gut commensal Megasphaera elsdenii: Relatedness and metabolic potential compared to animal isolates

This study compares Megasphaera elsdenii genomes from human and animal gut isolates, finding they are genetically similar and share metabolic functions, with no host-specific clustering or virulence genes.

Coordinated orienting behavior emerges following unilateral optogenetic activation of Superior Colliculus GABAergic neurons

This study shows that activating GABAergic neurons in the superior colliculus of mice triggers a coordinated sequence of orienting movements involving multiple effectors.

Mental replay rescales the subjective duration of past events via alpha and theta oscillations

The paper shows that mentally replaying past events at different speeds changes perceived duration through alpha and theta brain oscillations, without affecting memory content.

Thermodynamic Model and Experiments Indicate Kinetically Trapped States in Ionisable Lipid Nanoparticles

This study combines experiments and simulations to develop a continuum model explaining pH-dependent mesophase transitions in ionizable lipid nanoparticles and identifies metastable states.

When Does Active Learning Improve ADMET Prediction? A Multi-Endpoint Benchmark

This paper benchmarks active learning strategies for ADMET prediction, finding benefits vary by endpoint and strategy, with Deep Ensembles showing better predictive performance than MC Dropout.

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

Reinforcement Learning Reveals Spatial Strategies for Slowing Biological Invasions

This paper uses reinforcement learning to develop strategies for slowing biological invasions by optimizing spatial control efforts across heterogeneous landscapes.

High-resolution temporal profiling reveals synchronized dynamics of the mouse gut microbiome

This study reveals synchronized temporal dynamics in the mouse gut microbiome using high-resolution sampling and analysis methods, showing phase-coherent groups linked to host circadian cycles.

Neuroinflammation is an early pathological process in a mouse model of prodromal Parkinsons disease

This study shows that neuroinflammation occurs early in a mouse model of prodromal Parkinson's disease before neuronal loss, linking Syn pathology to olfactory dysfunction.

GLESKit: an MCP-based system for gene-level biomedical investigation and evidence synthesis

GLESKit is a gene-centered system that synthesizes biomedical evidence by integrating multiple data types, achieving high report quality and performance in benchmark tasks.