A. J. O'Donoghue

Development of subunit selective proteasome substrates for Schistosoma species

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

Development of subunit selective substrates for Trichomonas vaginalis proteasome

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system

This study characterizes globupain, a thermostable C11 protease from an Arctic hydrothermal vent, revealing its activation mechanism, substrate preference, and thermal stability.

Small Molecule in situ Resin Capture - A Compound First Approach to Natural Product Discovery.

This paper introduces a compound-first approach to natural product discovery called SMIRC, which captures structurally complex small molecules directly from environments, leading to the discovery of new compounds and classes.

Development of Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors with Negligible Cytotoxicity

This study develops highly selective epoxyketone-based proteasome inhibitors effective against Plasmodium falciparum with low cytotoxicity to human cells.

Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

The paper identifies a DPP4 homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness, showing it is inhibited by diabetes drugs.

Identification of a Papain-Like Protease Inhibitor with Potential for Repurposing in Combination with an Mpro Protease Inhibitor for Treatment of SARS-CoV-2

The paper identifies eltrombopag as a PLpro inhibitor that can be repurposed for SARS-CoV-2 treatment, effective in combination with Mpro inhibitors.

Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors

The paper identifies novel non-covalent and covalent inhibitors of SARS-CoV-2 main protease through virtual docking and experimental validation.

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

This study identifies naphthoquinone derivatives as inhibitors of SARS-CoV-2 proteases Mpro and PLpro through virtual screening and biochemical assays.

Discovery of Potent Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L

This paper identifies potent triple inhibitors targeting SARS-CoV-2 proteases and human cathepsin L, showing improved potency and antiviral effects compared to disulfiram.

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

A single-cell RNAseq atlas of the pathogenic stage of Schistosoma mansoni identifies a key regulator of blood feeding

This study uses single-cell RNAseq to analyze adult Schistosoma mansoni parasites, identifying a key regulator of blood feeding and gut maintenance.

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL

This study investigates the catalytic properties of the mitochondrial rhomboid protease PARL using in vitro assays, revealing substrate preferences and activity enhancements under specific conditions.

Giant magnetoresistive biosensors for real-time quantitative detection of protease activity

This study develops a giant magnetoresistive biosensor to detect protease activity by measuring magnetic nanoparticle release, showing sensitivity to papain in urine.