H. Park

The paper reprograms human B cells to express HCDR3 regions of HIV-1 bNAbs, enabling diverse and physiologic repertoires that efficiently bind HIV-1 antigens.

This paper introduces metrics to group pathology cohorts for deep learning cancer diagnosis, balancing model count and performance without linearly increasing models with cohort numbers.

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

The paper improves protein-ligand docking by optimizing force field parameters using small-molecule crystal structures, achieving better binding structure prediction.

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

The paper identifies carboxylesterases and lysosome-related organelles as essential for modular metabolite assembly in C. elegans, including ascarosides and glucosides.

This study identifies CAR/Nr1i3 as a regulator of T cell adaptation to bile acids in the small intestine, showing its role in detoxification and inflammation resolution.

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

This study identifies pyronaridine and artesunate as potential antiviral drugs effective against SARS-CoV-2 and influenza viruses in human lung cells.

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

This study identifies CCM1 as a regulator of YAP/TAZ signaling that promotes prostate cancer metastasis and is inversely correlated with patient survival.

The paper improves protein mutational free energy prediction by creating a balanced benchmark set and testing enhancements in the Rosetta software suite.

This study shows PICH is required for organizing SUMOylated proteins on mitotic chromosomes, ensuring proper chromosome segregation through its DNA translocase activity and SUMO-binding ability.

This paper introduces a rapid antimicrobial susceptibility test using laser speckle dynamics to detect bacterial growth in 2-4.5 hours.

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

This study shows PICH promotes dissociation of SUMOylated TopoII from mitotic chromosomes, ensuring proper chromosome segregation.

The paper introduces an improved energy model for protein-protein and protein-ligand docking that accounts for coordinated water molecules, enhancing native structure recovery.

The paper designs Liver-Chips for rat, dog, and human to replicate species-specific liver toxicities and predict human relevance.

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.

This study compares the ATPase mechanisms and microtubule interactions of NOD and KID chromokinesins, revealing distinct structural and biochemical pathways for similar functions during cell division.

The paper develops a molecular beacon imaging method using graphene-oxide quenching to visualize miR-193a transfer via exosomes during neurogenesis on a microfluidic platform.

The paper identifies a potent and selective ROR1-targeting scFv, R11, and determines its structure bound to ROR1, showing its antitumor activity in vitro and in vivo.

The paper explains the Rosetta all-atom energy function, its mathematical models, and its application to biomolecular modeling and design, including new capabilities for membrane proteins and other macromolecules.

This study examines melittin's effects on human red blood cells using quantitative phase imaging, revealing morphological, biochemical, and mechanical changes.

This study uses 3-D quantitative phase imaging to analyze morphological, biochemical, and mechanical properties of red blood cells from diabetic and non-diabetic patients, finding reduced sphericity, higher haemoglobin content, and lower membrane deformability in diabetic RBCs.