H. Xu

This paper introduces a new cryo-EM support film using HFBI protein 2D crystals to improve protein structure resolution by reducing preferred orientation and denaturation during vitrification.

This paper demonstrates that thin-film freeze-drying produces stable aerosolizable dry powders of monoclonal antibodies for pulmonary delivery.

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

This study demonstrates that thin-film freeze-drying can convert MF59 or AddaVax-adjuvanted vaccines into dry powders while preserving immunogenicity and stability.

AUG-3387, a human monoclonal antibody, neutralizes SARS-CoV-2 variants and reduces viral load in hamsters when administered as a dry powder inhaler formulation.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study identifies Ubr1 as a ubiquitin ligase that promotes endo-phagy/autophagy to protect against endosomal and Ca2+-induced proteostasis stress.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

This study characterizes the flagellar collar in Borrelia burgdorferi, revealing its structural plasticity and essential role in spirochete motility through high-resolution in-situ structures.

Sorbitol promotes early flower bud differentiation in loquat by upregulating the MADS-box transcription factor EjCAL through the ERF12 regulatory pathway.

This study shows PRMT7 inhibition enhances anti-tumor immunity and improves response to immune checkpoint blockade in melanoma by modulating immune cell infiltration and PD-L1 expression.

This study uses normal mode analysis and molecular dynamics simulations to investigate how alginate lyase produces quasi-monodisperse oligosaccharides by analyzing conformational changes and enzyme flexibility.

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

This paper reviews PhD career outcome tracking systems and creates a crosswalk tool to map similarities between taxonomies.

The paper investigates the roles of laminin-binding integrins in endothelial morphogenesis using organotypic culture models and identifies distinct functions for 6β1, 6β4, and 3β1.

This study demonstrates that thin-film freeze-drying can convert a Norovirus vaccine into a stable dry powder without antigen loss, enabling cold chain elimination.

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

The paper quantifies how two alternative promoters of the Bicoid target gene hunchback are differentially regulated by Bcd through enhancer-promoter interactions in Drosophila embryos.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

This study shows that hydroxychloroquine increases anxiety and depressive behaviors and alters gene expression in mouse brains, suggesting potential mental health risks.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper redetermines a protein structure originally solved by MicroED using XRD, comparing the results to assess MicroED's accuracy and limitations.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.

The paper examines how plant hydraulic and photosynthetic traits coordinate across species and elevations, finding that hydraulic traits are less plastic and more phylogenetically driven than photosynthetic traits.

This study identifies Arkadia-SKI/SnoN signaling as a regulator of TGF-β-induced iTreg differentiation, distinct from Th17 cell differentiation.

The paper refutes a claim that the universal genetic code is optimized for resource conservation by showing the original analysis had methodological errors.