H. Xu

This study examines how varying calcium concentrations affect the growth and encystment of Scrippsiella trochoidea, finding increased cell density and cyst formation at lower calcium levels, with reductions at higher concentrations.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

This paper identifies ORF3a as a SARS-CoV-2 viroporin that activates the NLRP3 inflammasome by causing potassium efflux, leading to IL-1β expression and inflammation.

This study investigates the role of WRKY31 and signaling compounds in enhancing insect resistance in Pinus massoniana L. against Dendrolimus punctatus by modulating hormone signaling pathways.

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

This study characterizes the 24-nt siRNA landscape in rice zygotes, revealing a redistribution towards the vegetative profile and epigenetic resetting before the first embryonic division.

This study shows that altering energy metabolism via IDH gene knockdown affects foraging behavior in termites, with social context modulating these effects.

This paper generates an acylsugar-deficient Nicotiana benthamiana mutant to improve studies of plant-insect interactions and virus transmission.

This study evaluates the efficacy and safety of combining ipratropium bromide and salbutamol in children and adolescents with asthma, finding reduced hospital admissions but no significant adverse event differences.

The paper develops deep learning algorithms to segment leaf vein networks and quantifies multi-scale architecture, revealing previously-undescribed variation across species.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

This paper develops a rapid, low-cost method to detect and quantify SARS-CoV-2 virus particles using nanoplasmonic sensors in microplate readers and smartphone devices.

The paper discovers a high-magnesium calcite armor in leaf-cutter ants, showing it enhances exoskeleton hardness and protects against predation and fungal infection.

This paper proposes a model of Hsp90-mediated kinase client activation, suggesting ATP-driven conformational changes enable clients to reach their active state.

This study evaluates the toxicity of miR-874 antagomiR and miR-146a in cardiomyocytes and cardiac fibroblasts, finding no significant effects on caspase activity or Ca2+ levels but potential impacts on MMP9 expression.

This paper develops a bio-active scaffold combining HMGB1 and kartogenin to enhance meniscus healing, showing activation of stem cells and promotion of tissue repair in vitro and in vivo.

The paper presents a stochastic simulation platform that models transcriptional kinetics and estimates reaction rates using a Gillespie algorithm and single-cell RNA imaging data.

This study shows that laminin-511 and α6 integrins regulate CXCR4 expression to promote endothelial morphogenesis and tube integrity.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper identifies how TGF-β signaling inhibition allows GATA4 to interact with JMJD3, promoting cardiomyogenesis by demethylating H3K27me3 at cardiac gene promoters.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This study identifies ACE2-expressing cells in the digestive system using single-cell transcriptomes, suggesting the digestive tract as a potential route for 2019-nCov infection.

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

This paper presents a protocol for high-throughput immunofluorescence of suspension cells, enabling systematic protein localization analysis in hematopoietic cells.

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

This study shows that alpha 6 integrins regulate cytokinesis by controlling RSK2 and MKLP1 expression in salivary gland epithelial cells.