J. Chang

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

This study shows that Sox2 forms DNA condensates that exert mechanical forces up to 7 pN, but chromatin nucleosomes reduce this force by sequestering Sox2.

This study develops a T cell-based method to distinguish between SARS-CoV-2 infection and vaccination by analyzing T cell reactivity to specific epitopes, achieving high classification accuracy across different groups.

This study investigates the genetic basis of herbicide resistance in blackgrass, finding that target-site resistance primarily arises from standing genetic variation rather than de novo mutations.

The paper develops an optogenetic probiotics system to control enteroendocrine hormone secretion in vivo, demonstrating improved glucose control in animal models.

This study compares glomerular function and urinary biomarkers in rats treated with vancomycin alone versus vancomycin plus piperacillin-tazobactam, finding no worsening of kidney function with the combination.

This study shows ICOS costimulation is essential for Tfr cell differentiation during GC reactions and highlights their role in immune tolerance.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This study measures binding affinity landscapes of two influenza bnAbs to understand their evolutionary pathways and how they acquire breadth.

This study uses urinary metabolomics in a rat model to show that taurine levels increase on day 1 of polymyxin B treatment and correlate with kidney injury markers.

This study shows that circadian-regulated endocytic recycling is essential for collagen fibril assembly and is disrupted in fibrosis.

This study shows that copper competition between methanotrophs and denitrifiers in rice paddy soils increases nitrous oxide emissions through methanobactin-mediated copper sequestration.

This study identifies 35 FDA-approved drugs that reduce SARS-CoV-2 replication in human cells, including amodiaquine and vitamin D3.

This paper shows that an engineered RBD with glycosylation sites improves immunogenicity and expression efficiency in SARS-CoV-2 vaccines.

This study examines how different metabolic environments affect three cancer cell phenotypes: drug survival, migration, and lactate overflow, revealing quantitative relationships between metabolism and cell behavior.

This study identifies LY6E as a host protein that restricts entry of human coronaviruses, including SARS-CoV-2, through a mechanism distinct from IFITM3.

This study investigates how thermal stress and acrolein, a smoke toxin, affect airway epithelial barrier function by altering ion transport pathways and tight junction integrity.

This study shows that the fibrinolytic niche regulates alveolar type 2 cell function and regeneration through the uPA-A6-CD44-ENaC cascade, with implications for lung injury repair.

The paper uses single-cell RNA sequencing to study CD8+ T cell differentiation during infection, revealing molecular determinants and functional heterogeneity in tissue-resident memory cells.

This paper investigates carbon metabolism, transcriptome, and RNA editome changes during developmental path differentiation in Coprinopsis cinerea, revealing key metabolic pathways and evolutionary transcriptomic patterns.

This study identifies VCP/p97 as essential for flavivirus nucleocapsid disassembly using a YFV entry reporter system.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This study identifies a three-dimensional differentiation hierarchy of keratinocytes in the tympanic membrane using single-cell RNA sequencing and live-cell imaging.