J. Choi

The paper shows that age-induced P-bodies in yeast shorten lifespan and are detrimental, with cytosol acidification exacerbating this effect.

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

The paper compares DNA and RNA microbial communities in Miscanthus x giganteus soil under different nitrogen fertilization rates, finding RNA-based communities better reflect nitrogen-cycling taxa.

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

The paper develops DNN models to estimate BLM-based PNECs for copper in freshwater using different input variables, showing improved predictive performance compared to existing tools.

This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.

This paper introduces a novel algorithm to estimate ants' walking speed and curvature on convoluted trajectories, showing it is more reliable than the conventional SLD method.

DARTE-QM is a method using high-throughput sequencing to detect antibiotic resistance genes in environmental samples, demonstrating efficiency and scalability.

This study identifies TXNRD3's role in redox regulation during epididymal maturation, showing its impact on mitochondrial function and sperm motility in mice.

The paper fine-maps melanoma-associated genomic regions to identify novel causal SNPs in the MTAP/CDKN2A and CASP8 loci using sequencing, variant filtering, and functional assays.

This paper develops a real-time single-molecule RNA sequencing method to visualize telomerase catalysis and structural dynamics at single-nucleotide resolution.

The paper identifies an IL-1β-Notch-Fosl2 axis that regulates differentiation plasticity of airway progenitors during alveolar regeneration.

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

This study integrates cancer cell phylogeny with mutational signature deconvolution to track mutational process changes in lung cancer patients over time.

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

This study shows that epigenetic DNA methylation variation in Arabidopsis thaliana affects complex traits and phenotypic diversity in natural populations.

This study investigates how genetic alterations affect EGFR-driven lung cancer growth and therapy response using a mouse model and CRISPR-Cas9 editing.

This study evaluates the therapeutic potential of FR, a Gq/11 inhibitor, in uveal melanoma by testing its effects on tumor growth, apoptosis, and metastasis in cell lines and xenograft models.

This paper introduces PRIME-Del, a prime editing method for precise genomic deletions, showing higher precision than CRISPR/Cas9 and enabling deletions with non-PAM junctions.

This study uses high-speed single-molecule TIRF microscopy to show that actively translating ribosomes undergo partial spontaneous rotations between three states, bridging conflicting models of ribosome dynamics.

This study shows that combining CD45-targeted ADCs with baricitinib enables effective allogeneic HSCT with high donor chimerism and reduced graft-versus-host disease.

The paper examines the evolutionary changes in GIV/Girdin's modularity, interactome, and functions across invertebrates and vertebrates, revealing distinct roles in cancer as tumor suppressor or oncogene.

This study identifies novel transcriptional networks and pathways linked to platinum-based chemotherapy resistance in high-grade serous ovarian cancer using integrated mRNA and microRNA data.

The paper estimates the phylogeny of Buxaceae using molecular data from four chloroplast markers and nuclear ribosomal ITS, describing new subfamilies, genera, and species.

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

This paper constructs a whole-proteome tree of insects without sequence alignment, finding an explosive emergence of major groups near the root and a basal Hemiptera subgroup.

This study evaluates global scientific bottom trawl data to assess challenges in tracking climate-driven marine species redistributions and proposes a framework for improved data sharing and management.

The paper identifies DATPs as a novel progenitor population in alveolar regeneration and shows how IL-1β-mediated inflammation impairs their differentiation into mature AT1 cells.