J. Fan

This study identifies three ATP-dependent phases in H2A.Z deposition by SWR1C using single-molecule and ensemble methods, revealing a priming step and ATP concentration-dependent release of H2A/H2B.

This study shows that C. elegans vertically transmits gut bacteria to offspring, which colonize tissues during development and influence immunity.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

The paper develops a cDNA display combined with next-generation sequencing platform to analyze transglutaminase 2 substrate preferences, revealing comprehensive amino acid preferences at specific peptide positions.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

A natural allele of rice UMP1 promotes resistance to multiple pathogens by boosting H2O2 accumulation.

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

This paper develops a chemiluminescence immunoassay for detecting ASFV antibodies in serum, showing high specificity, sensitivity, and consistency with a commercial kit.

This study investigates SIM artifacts caused by light scattering in thick samples and shows how sample thickness affects 2D-SIM image reconstruction.

This study maps the spatial organization of RNA in individual neurons using MERFISH, revealing distinct transcriptome compositions and sub-dendritic RNA distribution patterns.

This paper shows that neutrophils use reversed upper glycolysis and rapid oxidative pentose phosphate pathway activation to support the oxidative burst, a key immune response.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

This study identifies IL-22's role in renal metabolic reprogramming through PFKFB3 to treat kidney injury in animal models.

This paper uses in vivo FLIM to track metabolic changes in macrophages during wound responses in zebrafish, showing dynamic shifts in NAD(P)H and FAD redox ratios.

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

The paper develops an IP-MS assay to identify slow-growing mycobacterial species in early MGIT cultures using species-specific antibodies.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

The paper identifies Mps2 as a mediator forming a heterotrimeric telomere-associated LINC complex in budding yeast meiosis, linking Csm4 and Mps3.

This study reports cryo-EM structures of the A. baumannii MLA complex in different states and proposes a molecular mechanism for lipid transport.

The paper identifies 56 beneficial genes for optimizing free fatty acids production in E. coli using CRISPRi-Omics and reports a record FFAs titer of 21.6 g L-1.

This study shows that knocking down Glut-1 in HEp-2 cells increases autophagy, reduces cell viability and migration, and promotes apoptosis through Beclin-1 regulation.

The paper develops and validates a method to quantify acetylation stoichiometry, revealing dynamic changes in response to serum stimulation across cellular compartments and pathways.

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

This study shows IL-22 improves liver injury by promoting metabolic reprogramming and mitochondrial function through a signaling pathway involving AMPK, AKT, and mTOR.

This study investigates the molecular mechanism of PA transfer by Ups1/Mdm35 using crystal structures, molecular dynamics simulations, and biophysical assays, revealing conformational changes and regulatory factors.

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.

This study characterizes heparin-induced tau filaments using cryo-EM and immuno-EM, revealing structural diversity and differences from Alzheimer’s and Pick’s disease filaments.

This study identifies the Mla system in Acinetobacter baumannii as essential for glycerophospholipid transport to the outer membrane and antibiotic resistance.