J. Johnson

Immune modulatory effects of probiotic streptococcuc thermophilus on human monocytes

This study shows that Streptococcus thermophilus modulates human monocyte gene expression, decreasing pro-inflammatory markers and increasing cytokine expression, suggesting potential benefits for inflammatory and autoimmune diseases.

Discovery of A New Class of Integrin Antibodies for Fibrosis

The paper identifies new integrin antibodies that inhibit fibrosis progression in lung injury models and show superior in vitro activity in fibroblasts.

Development of a Coronavirus Disease 2019 Nonhuman Primate Model Using Airborne Exposure

This study infects nonhuman primates with SARS-CoV-2 via airborne exposure and compares disease progression across species.

Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube

This study shows PD-1 and its ligands are expressed by ovarian and fallopian tube cells, with functional implications for T cell regulation and immune privilege in reproductive tissues.

Eliciting OTUD3/RIPK-Dependent Necroptosis to Prevent Epithelial Ovarian Cancer

This study investigates necroptosis as a potential prevention strategy for high-grade serous ovarian cancer by analyzing gene expression and testing treatments that induce necroptosis in HGSOC cells.

The Past, Present and Future of Elephant Landscapes in Asia

The paper quantifies historical and future habitat loss for Asian elephants across multiple scenarios, showing significant declines and the need for equitable policies.

Do mechanical strain magnitude and rate drive bone adaptation in adult women? A 12-month prospective study.

This study investigates how mechanical strain magnitude and rate affect bone adaptation in adult women over 12 months, finding that higher strain rates and loading doses correlate with increased bone mineral content.

Collagen Production and Niche Engineering: A Novel Strategy for Cancer Cells to Survive Acidosis and Evolve

The paper identifies collagen production as an adaptation strategy in acidotic cancer cells, showing correlation with patient survival.

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

Two accessory proteins govern MmpL3 mycolic acid transport in mycobacteria

This study identifies two new proteins involved in the MmpL3-mediated mycolic acid transport in mycobacteria, revealing their roles in transport and stress response.

Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases

This study shows proscillaridin, a cardiac glycoside, selectively targets MYC overexpressing leukemia by downregulating histone acetyltransferases and inducing hematopoietic differentiation.

Induction of AMPK activation by N,N-Diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers

This paper tests the effects of FND-4b, a novel AMPK activator, on breast cancer cell proliferation and apoptosis, finding it reduces growth and increases apoptosis in both estrogen-receptor positive and triple-negative breast cancer cells.

Effect of chromatin flexibility on diffusive loop extrusion via molecular slip-links

This study shows that chromatin stiffness and proximity of cohesin and CTCF sites enhance diffusive loop extrusion efficiency.

Evolutionary proteomics uncovers ciliary signaling components

The paper uses proteomic analysis of cilia from diverse organisms to identify conserved ciliary proteins and their ancient signaling connections, revealing a novel protein involved in vertebrate development and human disease.

Non-equilibrium chromosome looping via molecular slip-links

This paper introduces a model for chromatin loop formation through diffusive sliding of molecular slip-links, showing it can explain experimental biases without requiring motor activity.