J. Wu

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

This study examines how soluble proteins and kernel hardness affect starch digestibility in wheat flour, finding that soluble proteins significantly reduce digestion even after gastric proteolysis.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This paper uses single-molecule nanopore dielectrophoresis to study α-Synuclein folding and unfolding in lipid membranes and how metal ions and peptidomimetics affect these processes.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

This study investigates how different regions of the prion protein influence membrane permeabilization using single-channel electrical recordings.

The paper investigates how CP110 and CEP97 regulate microtubule plus-end dynamics and centriole biogenesis through direct interactions and synergistic effects.

This study shows that homologous or heterologous boosters of inactivated vaccines increase neutralizing antibodies against SARS-CoV-2 Omicron, reducing escape from neutralization.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

This study shows that PRC2 heterogeneity in SHH medulloblastomas drives tumor growth through intrinsic and non-cell autonomous mechanisms involving IGF2.

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

The paper trains a machine learning model to detect clonal hematopoiesis in cancer patients using cell-free DNA sequencing and characterizes associated tumor microenvironment changes.

This study identifies LRRC23 as a conserved component of the radial spoke complex in mouse sperm, essential for flagellar motility and male fertility but not ciliary function.

This study develops a serum-free culture condition (DA-X) that supports cancer cell proliferation and survival, enabling analysis of cholesterol's role in cell adhesion and growth.

The paper identifies a consistent spectral signature of lianas across scales, showing their detectability from space but highlighting challenges in accurate remote sensing due to trait overlap with other species.

The paper identifies two helices that regulate the conformation and function of the kinase domain in LRRK2 through dynamic crosstalk.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows that rod-shaped particles create granular hydrogels with better pore structure and cell invasion compared to spherical particles.

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.