J. Wu

This study shows TRIM47 enhances endothelial activation and pulmonary inflammation by promoting K63-linked ubiquitination of TRAF2, leading to NF-κB and MAPK pathway activation.

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.

The paper detects Phytophthora cinnamomi in Carya cathayensis using loop-mediated isothermal amplification and confirms its association with dieback disease.

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

This study shows TET1 facilitates DNA demethylation of the Cxcl1 promoter, enabling its induction and neutrophil recruitment during acute lung injury.

This study identifies and analyzes CRISPRs in infant gut microbiomes, finding they are associated with bacterial expansion and influenced by gender.

This study identifies the structural basis of polyglutamine nucleation, showing that a four-stranded steric zipper initiates aggregation and poisons further growth.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

This study shows that PCM can self-assemble into a compact MTOC in interphase cells without centrioles, using dynein transport and self-clustering, but this process is sensitive to motor and microtubule dynamics.

This study compares a wild-type SARS-CoV-2 spike protein DNA vaccine with an optimized sequence in a mouse model, showing enhanced immune responses and protection against viral challenge.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

The paper investigates how genetic variants in the ACE2 gene affect susceptibility to SARS-CoV-2 infection by analyzing their impact on viral entry.

This study examines the impact of virtual academic conferences during the COVID-19 pandemic, finding increased participation from underrepresented groups but also challenges in engagement and interaction, suggesting a hybrid format is preferable.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.

This study develops a molecular dynamic fingerprint (MDFP) and combines it with traditional fingerprints to predict hERG cardiotoxicity, achieving higher accuracy than single-fingerprint models.

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.