J. Wu

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

This study uses simulations and HDX-MS to analyze how two LRRK2 inhibitors affect the protein's conformational dynamics and kinase activity.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study examines how elephants adjust their trunk grip strategies for different weights and finds that heavier weights are associated with increased wrapping surface area and constant tensile force.

The paper identifies PELO as a catalyzer required for the ATPase activation and sequential assembly of NLR family proteins into functional complexes.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

This study shows that planting diverse tree mixtures in logged forests accelerates restoration rates in a large field experiment.

The paper establishes and characterizes a continuous Atlantic mackerel skeletal muscle cell line with myogenic and adipogenic-like phenotypes.

The paper develops a single-cell multi-omics platform to simultaneously profile transcriptome and proteome in mouse oocytes, revealing transcriptome-proteome heterogeneity and identifying maturational signatures.

This study develops a stapled peptide inhibitor that blocks talin-induced integrin activation by targeting both talin head and rod domains.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

This study characterizes a Mycobacterium tuberculosis dipeptidyl peptidase with high thermal stability and shows its potential role in immune modulation.

This study identifies the OsNLP4-OsMADS27 module as a nitrate-dependent regulator of salt tolerance in rice, showing its role in stress response and yield improvement under salt stress.

This study identifies IL-1 and LIF as factors promoting EMH by activating splenic niche cells and inducing an inflammatory gene signature in HSPCs.

This study reports cryo-EM structures of modified IGF1R and IR complexes, showing that disulfide-linked CTs are critical for receptor activation and signaling.

The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.

The paper develops PiSPA, a single-cell proteomic workflow, to quantify up to 3000 protein groups in tumor cells, demonstrating its utility in studying single-cell proteome dynamics.

Fossil-explorer.com is an interactive tool for exploring fossil data that addresses visual clutter and limited interaction, efficiently handling millions of data points.

This study ablates SYK kinase in primary human NK cells using CRISPR/Cas9, finding it enhances cytotoxicity and cytokine production compared to other gene ablations.

This study shows NEMP1 is essential for nuclear envelope openings and enucleation in erythroblasts, leading to anemia and splenomegaly in Nemp1 knockout mice.

This study shows that neutrophil-tropic nanoparticles enhance phagocytosis of non-opsonized bacteria by ~50%, suggesting their potential as drug carriers for bacterial infections.

This study compares genomes of orobanchaceous plants with different parasitic lifestyles to trace the evolutionary steps of plant parasitism.

This study identifies early urinary biomarkers in a rat model of multiple sclerosis and shows that early treatment with methylprednisolone reduces disease incidence.

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.