J. Zhang

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study identifies het genes in Aspergillus fumigatus involved in heterokaryon incompatibility and shows that balancing selection acts with a narrow genomic footprint despite high recombination rates.

This study uses optically pumped magnetometers to measure the intestinal magnetic field of a rabbit, showing their potential for noninvasive disease detection.

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

This study identifies FAP106 as a critical interaction hub for assembling conserved and lineage-specific microtubule inner proteins at the cilium inner junction in Trypanosoma brucei.

The paper identifies a shared genomic region upstream of Myc that is critical for both intestinal regeneration and cancer, revealing a genetic link between tissue renewal and tumorigenesis.

This study shows FBXO7 is not required for PINK1/Parkin-dependent mitophagy in HeLa and iNeuron cells, as its absence does not impair key mitophagy processes.

This paper introduces PS-ApTCs, a novel PROTAC design using aptamers for spatioselective degradation of nucleocytoplasmic shuttling proteins, showing enhanced efficacy and synergistic effects in cancer therapy.

This study uses a rodent model of hyperglycemia to show that proinsulin trafficking is delayed at the Golgi, contributing to beta-cell secretory dysfunction in Type 2 diabetes.

The paper uses RS-mimic peptides to study phase separation of SRSF1, revealing that combined stacking and electrostatic interactions drive this process.

The paper shows that aligned extracellular fibers enable faster, more efficient collective cell migration by enhancing force transmission and front stabilization.

The paper uses super-resolution imaging to show that different RNA sequence domains localize to distinct regions within nuclear speckles, driven by RNA-protein interactions.

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

This study uses scRNA-Seq to analyze B cells from allo-HCT patients, revealing molecular differences in B cell subsets associated with active versus non-active cGVHD.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

This study identifies Numb as a ciliary protein that promotes Hedgehog signaling by facilitating Ptch1 exit from the cilium through endocytic mechanisms.

The paper shows that S-nitrosylation of IAA17 at Cys-70 inhibits its degradation and reduces auxin signaling, affecting plant development.

The paper develops a new optical technique to capture the mechanical evolution of neural plate tissue during neural tube closure in live chick embryos.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study shows that disrupting mitochondrial Ca2+ homeostasis in Arabidopsis leads to misregulated gene expression and proteostatic responses, affecting plant growth and stress resistance.

This paper identifies IRS4 as a novel regulator of TRPM6 channel activity and Mg2+ homeostasis, showing IRS4 mediates insulin's effect on TRPM6 phosphorylation and Mg2+ absorption.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper develops a single-cell MRD assay that detects residual leukemic clones with high sensitivity and reveals clonal architecture in AML.

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of 293T cell membranes, showing lipid bilayer thickness and protein distribution.