J. Zhu

This study shows that SARS-CoV-2 Nsp14 activates NF-κB signaling and increases IL-8 expression, which is confirmed in infected cells and lung tissue from COVID-19 patients.

This study examines how temperature affects the behavior and molecular responses of Neptunea cumingii, showing significant physiological and transcriptomic changes outside the optimal temperature range of 8–16°C.

The paper uses CRISPR-Cas9 tiling screens to identify functional domains in human mitotic proteins, revealing new regions essential for cell proliferation and chromosome segregation.

This paper develops a nanomedicine approach to restore PLPP3 in endothelial cells, reducing YAP/TAZ activity and atherosclerosis in mice.

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

This paper develops a CRISPR-engineered bacteriophage T4 nanoparticle platform to create multiplex SARS-CoV-2 vaccine candidates, showing potent immune responses and protection in animal models.

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.

This study shows Synaptojanin1 deficiency increases basal autophagosome formation in astrocytes, with implications for Parkinsonism.

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

This paper designs a biomimetic aramid nanofiber nanocomposite insulation material for implantable bioelectronics using graph theory analysis to mimic cartilage structure, showing improved adhesion and biocompatibility compared to Parylene C.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

This study shows that KSHV modulates polyamine biosynthesis and eIF5A hypusination to promote viral infection and oncogenesis, identifying these pathways as therapeutic targets.

Overexpressing EiKCS from goosegrass in rice increases polyamine levels and enhances paraquat tolerance through improved antioxidant capacity and photosynthesis.

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

This study identifies gene mutations in the PI3K/Akt pathway associated with immune thrombocytopenia (ITP) using whole-exome sequencing and functional analysis.

This study identifies distinct lineage states in small cell lung cancer driven by c-Myc and L-Myc, showing their unique roles in molecular subtypes and histology.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This paper shows that K777, a cysteine protease inhibitor, blocks SARS-CoV-2 infection by inhibiting host cathepsin L, which is required for spike protein processing, with nanomolar efficacy in several cell lines.

This study shows that inhibiting PLK1 promotes reactivation of KSHV and EBV in B-cell lymphomas, leading to cell death, and identifies PLK1 as a potential therapeutic target for HIV-positive patients.

This paper introduces a scaffolded learning method for bipedal walking in robots, showing that performance-based scaffolding accelerates ontogenetic development.

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

The paper develops SARS-CoV-2 vaccine candidates by displaying the receptor-binding domain and a stabilized spike on self-assembling protein nanoparticles, showing enhanced neutralizing antibody and T-cell responses.

This study identifies immunodominant and neutralizing epitopes on SARS-CoV-2 proteins through computational simulation and experimental validation in mice.

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

The paper identifies lanthipeptide synthetases as key enzymes in the biosynthesis of 2-aminovinyl-cysteine motifs in thioamitides, revealing their role in dehydration and macrocyclization.

The paper develops a CAR RNA FISH assay to study the trafficking and function of CAR T cells in mouse tissue at single-cell resolution.