L. Chen

This study shows that Lactobacillus rhamnosus reduces GBS-induced cytotoxic effects on HeLa cells by preserving microvilli, vesicles, and F-actin structures.

This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

The paper investigates X chromosome expression ratios across development and evolution, finding dynamic X:AA ratios but stable dosage compensation in mammals.

The paper introduces OPAM, a low-cost, 3D-printed micromanipulator for single cell manipulation, demonstrating its ability to capture and transfer single cells under a microscope.

The paper shows warmer temperatures during the previous growing season advance spring phenology in the Northern Hemisphere, with a decline in this effect over time.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

The paper identifies PSMB3 as a contributor to gliomagenesis through proteasome-dependent and independent mechanisms using a CRISPR-Cas9 screen in GBM.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper shows that leaf senescence timing shifts in response to seasonal warming, with advances or delays depending on when warming occurs during the growing season.

The paper analyzes transcriptome and metabolome data from plum fruits at different developmental stages to identify pathways and genes associated with fruit color changes.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study identifies ARF4 as a driver of chemoresistance in glioblastoma through a CRISPR screen and shows it mediates retrograde trafficking of EGFR into the nucleus.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

The paper describes a new lobeattid insect species from the Pennsylvanian period, revealing its morphology and ecological role as an omnivorous ground egg-layer with a specialized ovipositor.

The paper develops a fluorescent polarization assay to screen SARS-CoV-2 fusion inhibitors, showing effective inhibitors with sub-mM concentrations and validating the assay with a high Z factor.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

A strain-programmable bioadhesive patch accelerates wound closure and healing in diabetic mice and human skin.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This study shows that basic fibroblast growth factor (bFGF) undergoes liquid-liquid phase separation on the cell surface with heparan sulphate proteoglycans (HSPG), which is essential for downstream signaling.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study shows TTC36 protects renal tubular cells from cisplatin-induced apoptosis by maintaining mitochondrial homeostasis and autophagy.

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.