L. Zhou

This paper develops a framework for generating device-specific optimal PSFs for 3D super-resolution imaging using deformable mirrors, demonstrating superior performance over conventional PSFs.

The paper designs a DNA nanostructure for rapid, sensitive, and inexpensive detection of SARS-CoV-2 and demonstrates its potential to inhibit viral infection.

This study identifies ILC3s as key regulators that promote RORγt+ Tregs and suppress Th17 cells to maintain intestinal tolerance to microbiota.

FebRNA predicts RNA 3D structures using a fragment-ensemble-based approach, achieving reliable results for complex RNA topologies.

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

This study compares T cell responses in children and adults with mild/asymptomatic COVID-19, finding differences in T cell diversity and memory formation.

Unadjuvanted intranasal spike vaccine booster generates broad sarbecovirus protective mucosal immunity in a preclinical model.

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

The paper uses genomic data to show that natural selection and demographic history jointly shaped the genetic structure and contact zones in Norway spruce during post-glacial recolonization.

The paper reports the cryo-EM structure of the budding yeast Smc5/6 holo-complex, revealing its architecture and interactions between subunits.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

The paper investigates nonenzymatic RNA copying using 2AI-bridged dinucleotides, finding that sequence-dependent differences in binding and reaction rates limit template copying.

The paper examines ER exit sites in Drosophila, finding pre-cis-Golgi regions and pearled tubes but no megacarriers for ER-Golgi transport.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

The paper identifies CB002 analogues that restore p53 signaling and target an S-phase checkpoint in p53-mutated tumors, inducing apoptosis and reducing proliferation without harming normal cells.

This study shows that EGCG from green tea inhibits SARS-CoV-2 and its variants by blocking spike protein binding to ACE2 receptors.

This study shows BRAF inhibitors reprogram cancer-associated fibroblasts to promote matrix remodeling and resistance to therapy in melanoma by enhancing β-catenin signaling and POSTN expression.

This study identifies Nse5/6 as a negative regulator of Smc5/6 ATPase activity in S. cerevisiae by showing it suppresses ATP turnover through binding to the complex head-end.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

This study shows that TTP overexpression prevents gastric inflammation and metaplasia in mice by suppressing innate immune genes, with partial protection linked to Tnf suppression.

FOD-Net improves angular resolution of FOD images from clinical dMRI data to match research-quality data, enabling better tractography and connectome reconstruction.

This study uses AFM-IR spectroscopy to show that phospholipids differentially affect the secondary structure of α-synuclein oligomers, with phosphatidylcholine and phosphatidylserine leading to distinct structural outcomes.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This paper identifies ZmLARP6c1 as a pollen-specific RNA-binding protein in maize, showing its role in competitive pollen tube growth through a mutant analysis.

This study shows that deleting Letmd1 in mice causes mitochondrial dysfunction in brown adipose tissue, leading to thermogenesis disruption and metabolic disorders.

The paper determines the cryo-EM structure of the human R2TP-TTT complex and shows how TTT recruits TOR to R2TP while regulating its chaperone activity.