M. Wang

This paper identifies Mettl3 as a p53-interacting protein that stabilizes p53 and enhances its tumor suppressive functions through both protein stabilization and m6A modification of p53 pathway transcripts.

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

The paper introduces an improved BacMam vector for efficient and safe protein production in mammalian cells.

This study shows Tranexamic Acid inhibits cancer growth by blocking Plasmin-mediated CDCP1 cleavage and disrupts multiple intracellular signaling pathways.

This study shows that type IV pili in bacterial consortia reduce spatial intermixing, forming a bubble-jet pattern that affects community productivity.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

This study uses phylogenetic analysis to infer the transoceanic dispersal history and foraging evolution of Kalotermitidae termites, finding that dispersal and human activity shaped their global distribution.

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

This paper reports the structure and function of Pseudomonas aeruginosa CtpA, showing it forms an inactive hexamer that requires the spiral-shaped lipoprotein LbcA for activation and substrate delivery.

This paper reviews selenium content in wheat farming soil, grain, and derived foods globally, showing how agronomic practices can enhance selenium levels in wheat and its products.

This study shows that anti-aggregation strategies in microbial space colonization enhance competitive success by increasing Space Accessibility, offsetting lower growth rates or initial abundance.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

This study assesses batch effects in TMA-based cancer biomarker studies and shows mitigation methods reduce variance and alter clinical associations.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

This study identifies renalase (RNLS) as a biomarker in pancreatic ductal adenocarcinoma (PDAC), showing elevated tissue and plasma levels correlate with worse tumor characteristics and reduced survival.

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

This study uses meta-analysis of DNA microarray data to identify gravity-sensitive genes, finding that SLCO2A1 expression decreases under microgravity.

This study shows that MFG-E8 promotes Ang II-induced arterial inflammation and remodeling in aging, and its deficiency reduces these effects.

This paper identifies a hamster model, Phodopus roborovskii SH101, that exhibits systemic SARS-CoV-2 infection with clinical symptoms similar to human COVID-19.

This study shows the SARS-CoV-2 P.1 variant is more resistant to antibody neutralization than previous variants, but less affected by vaccine-induced immunity.

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.