M. Wang

Dynamic changes of gut microbiota associated with blood glucose levels in sows from pregnancy through lactation

This study examines how restricted feeding during gestation affects blood glucose levels and gut microbiota in sows across pregnancy and lactation stages.

Algae community structure and relation to environmental factors in the Hulanhe Wetland, Northeast China

The study evaluates algae community distribution in the Hulanhe Wetland, finding that TN and TP are key environmental factors influencing algae composition.

Optical control of CRISPR-Cas editing with cyclically caged guide RNAs

This paper introduces a method to control CRISPR-Cas gene editing using light-activated circular guide RNAs, enabling precise spatial and temporal gene editing in cells and embryos.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

High Cellular Uptake Gene Delivery Platform with Chitosan and L-arginine Complex for Cancer Treatment

This study develops a chitosan-L-arginine complex for gene delivery, showing high encapsulation efficiency and enhanced cellular uptake of siRNA in cancer cells.

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

Phenotypic and transcriptomic responses of the sun- and shade-loving plants to sunlight and dim-light conditions

This study compares phenotypic and transcriptomic responses of sun- and shade-loving plants to sunlight and dim-light conditions, finding that shade-loving ginseng shows lower phenotypic plasticity but higher photosynthetic efficiency under dim light.

Hsa-miR-31-5p controls a metabolic switch in psoriatic keratinocytes that identifies therapeutic intervention

This study shows that miR-31-5p in psoriatic keratinocytes promotes a metabolic switch to glutamine metabolism, leading to immune-modulatory effects and Th17 cell differentiation, which can be inhibited by GLS targeting.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

Reduced mesophyll conductance by cell wall thickening and chloroplasts decreasing driven the decline of photosynthesis under sole NH4+ supply

This study shows that sole NH4+ supply reduces photosynthesis in Lonicera Japonica by decreasing mesophyll conductance, driven by thicker cell walls and reduced chloroplast surface area.

Intracranial Electric Field Recording During Multichannel Transcranial Electrical Stimulation

The paper measures in vivo electric fields during multi-electrode transcranial electrical stimulation and validates linear superposition and quasi-static assumptions.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

Digital restoration of the pectoral girdles of two Early Cretaceous birds, and implications for early flight evolution

The paper digitally reconstructs pectoral girdles of two Early Cretaceous birds, revealing morphological features and their implications for early flight evolution.

Using ultraconserved elements to reconstruct the termite tree of life

This paper develops a UCE bait set for termites to reconstruct their phylogeny using poorly preserved samples, showing congruence with transcriptome-based phylogenies.

SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by targeting a glycosyl hydrolase coding gene at transcriptional level

A nuclear import pathway exploited by pathogenic noncoding RNAs

The paper identifies a cellular pathway involving Importin alpha-4 and Virp1 that facilitates nuclear import of noncoding RNAs, including viroids and a subviral satellite RNA.

Historical biogeography of early diverging termite lineages (Isoptera: Teletisoptera)

This paper reconstructs the historical biogeography of early diverging termite lineages using genetic data, finding that their distribution resulted from both over-water dispersals and land bridge migrations.

Neoisoptera repetitively colonised Madagascar after the Middle Miocene climatic optimum

This study uses mitochondrial genomes to show that Neoisoptera colonized Madagascar 7-10 times during the Miocene, matching Australia's colonization timing and sharing similar taxonomic composition.

Structural insights into the mechanism of nucleotide regulation of pancreatic KATP channel

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

Robust and Efficient Assessment of Potency (REAP): A Quantitative Tool for Dose-response Curve Estimation

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

Bioequivalence Assessment of High-Capacity Polymeric Micelle Nanoformulation of Paclitaxel and Abraxane(R) in Rodent and Non-Human Primate Models Using a Stable Isotope Tracer Assay

DEAD-box RNA helicase 18 disrupts IRF3-binding to the interferon-β promoter

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation

This study shows that succinate dehydrogenase/complex II is essential for T cell proliferation and inflammation by regulating metabolic flux and epigenetic modifications.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.