M. Zhang

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.

The paper develops improved fluorescent proteins for dual-color post-embedding CLEM, enhancing signal-to-background ratio and reducing autofluorescence background.

This study finds that elevated SARS-CoV-2-specific T cells in individuals with pulmonary PASC correlate with increased inflammation and reduced lung function.

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

This study uses 2P-FLIM and machine learning to classify human macrophage polarization based on metabolic state, achieving high accuracy in distinguishing M1 and M2 phenotypes.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

The paper analyzes the distribution of virulence factors in Bacillus cereus strains using phylogenetic and protein prediction methods, revealing clustering based on virulence genes and structural features.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This paper describes an oral protein cocktail, LMN-201, for C. difficile infection, showing it achieves high cure rates and validates spirulina as a delivery platform.

The paper identifies POPDC1 as a novel scaffold for AC9 that regulates heart rate by interacting with TREK-1 in an isoproterenol-dependent manner.

This study identifies ESRRG as a novel dependency in retinoblastoma cells following RB1 loss, showing its role in retinogenesis and oxygen metabolism and suggesting it as a therapeutic target.

This study develops and tests a bivalent rVSV vaccine targeting SARS-CoV-2 Delta and influenza, showing strong immune responses and protection in animal models.

The paper introduces OtUBD, a bacterial deubiquitylase-derived domain for ubiquitin detection and purification, showing its effectiveness in isolating ubiquitylated proteins from yeast and human samples.

This study shows that elevated PGE2 in aged lungs impairs alveolar macrophages, leading to increased mortality from influenza infection.

This paper investigates the role of D1-E189 in PSII assembly, finding it is not required for Mn2+ binding but is critical for Ca2+ ligation and preventing mis-assembly of Mn.

This paper introduces SHARC, a method to measure RNA 3D distances and alternative conformations in cells, revealing RNA structures and improving 3D modeling.

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

This paper shows that the Wolbachia CinB nuclease alone can induce cytoplasmic incompatibility in Drosophila males, with rescue by cognate CifA in females.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

This study evaluates how different lighting conditions affect kratom plant growth and alkaloid synthesis, finding that shaded greenhouse conditions increase certain alkaloid concentrations and total leaf alkaloid yield.

This study shows that short-term adropin treatment does not improve cardiac function in diet-induced obese mice, but reduces inhibitory phosphorylation of pyruvate dehydrogenase in cardiomyocytes.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

This study uses MD simulations and NMR to identify a binding cavity in Galectin-3's CTD that interacts with its disordered NTD, and designs an inhibitory peptide targeting this interface.

This study shows that estrogen signaling through GPER increases GCN5L1 expression and MCAD activity in cardiac cells, affecting mitochondrial enzyme acetylation and metabolic fuel utilization.

This study uses cryo-electron tomography and deep learning to visualize the molecular organization of nucleosome phase separation stages, revealing a two-step process and the role of histone H1 in condensate transformation.

This study uses super-resolution microscopy to observe and quantify the heterogeneous growth of amyloid spherulites in real-time, revealing anisotropic growth pathways and energy landscapes.